Golgicide A | Tocris Bioscience 3584/10 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Golgicide A

catalog :

3584/10

quantity :

10 mg (also 50 mg)

price :

251 USD

citations: 5

Reference
Cerrato G, Leduc M, Müller K, Liu P, Zhao L, Humeau J, et al. Oleate-induced aggregation of LC3 at the trans-Golgi network is linked to a protein trafficking blockade. Cell Death Differ. 2021;28:1733-1752 pubmed publisher
English J, Olsen R, Lansu K, Patel M, White K, Cockrell A, et al. VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells. Cell. 2019;178:748-761.e17 pubmed publisher
Portela M, Segura Collar B, Argudo I, Saiz A, Gargini R, Sanchez Gomez P, et al. Oncogenic dependence of glioma cells on kish/TMEM167A regulation of vesicular trafficking. Glia. 2019;67:404-417 pubmed publisher
Gomes da Silva L, Jimenez A, Sauvat A, Xie W, Souquere S, Divoux S, et al. Recruitment of LC3 to damaged Golgi apparatus. Cell Death Differ. 2018;: pubmed publisher
Krokowski D, Guan B, Wu J, Zheng Y, Pattabiraman P, Jobava R, et al. GADD34 Function in Protein Trafficking Promotes Adaptation to Hyperosmotic Stress in Human Corneal Cells. Cell Rep. 2017;21:2895-2910 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3584

SKU :

3584/10

product name :

Golgicide A

description :

Potent, selective and reversible inhibitor of GBF1 ArfGEF

target :

ARF GTPase Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at RT

observed molecular weight :

284.3

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Golgicide A is a potent, specific and reversible inhibitor of Golgi BFA resistance factor 1 (GBF1), an ArfGEF, that decreases Arf1 activation in vivo . Arrests secretion of soluble and membrane-associated proteins at the endoplasmic reticulum-Golgi intermediate compartment. Causes disassembly and dispersal of the Golgi and trans -Golgi network.

product keywords :

potent specific reversible inhibitors inhibits Golgi BFA resistance factors 1 GBF1 ArfGEF ADP ribosylation factor guanine nucleotide exchange Arf Translocation 3584, ARF, ADP ribosylation factor, GTP ase,

extended description :

Potent, selective and reversible inhibitor of GBF1 ArfGEF

chemical name text :

6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline

formula :

C17H14F2N2

formula text :

C17H14F2N2

cas num :

1139889-93-2

USD :

278

USD 2025 :

251 USD

product details :

Potent, selective and reversible inhibitor of GBF1 ArfGEF