C 021 dihydrochloride | Tocris Bioscience 3581 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

C 021 dihydrochloride

catalog :

3581

quantity :

10 mg (also 50 mg)

price :

229 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Palchevskiy V, Xue Y, Kern R, Weigt S, Gregson A, Song S, et al. CCR4 expression on host T cells is a driver for alloreactive responses and lung rejection. JCI Insight. 2019;5: pubmed publisher
He W, Holtkamp S, Hergenhan S, Kraus K, De Juan A, Weber J, et al. Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues. Immunity. 2018;49:1175-1190.e7 pubmed publisher
Rasheed K, Abdulsalam I, Fismen S, Grimstad Ø, Sveinbjørnsson B, Moens U. CCL17/TARC and CCR4 expression in Merkel cell carcinoma. Oncotarget. 2018;9:31432-31447 pubmed publisher
Kwon M, Shin H, Cui Y, Kim H, Thi A, Choi J, et al. CCL2 Mediates Neuron-Macrophage Interactions to Drive Proregenerative Macrophage Activation Following Preconditioning Injury. J Neurosci. 2015;35:15934-47 pubmed publisher
McMillin M, Frampton G, Thompson M, Galindo C, Standeford H, Whittington E, et al. Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J Neuroinflammation. 2014;11:121 pubmed publisher

product information

brand :

Tocris

master code :

3581

SKU :

3581/10

product name :

C 021 dihydrochloride

description :

Potent CCR4 antagonist

target :

Chemokine Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

540.57

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent CCR4 chemokine receptor antagonist (IC50 values are 0.14 and 0.039 M for inhibition of chemotaxis in human and mouse respectively).

catalog number base :

3581

product keywords :

C021 dihydrochloride potent CCR4 chemokines receptors antagonists Chemokine CC Receptors 3581,

extended description :

Potent CCR4 antagonist

chemical name text :

2-[1,4 -Bipiperidin]-1 -yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine dihydrochloride

formula :

C 27 H 41 N 5 O 2 .2HCl

formula text :

C27H41N5O2.2HCl

cas num :

1784252-84-1

2020 USD :

218

2021 USD :

229 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage