product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
3581/10
catalog :
3581/10
quantity :
10 mg (also 50 mg)
price :
288 USD
more info or order :
citations: 7
Reference
Deng S, Jin P, Sherchan P, Liu S, Cui Y, Huang L, et al. Recombinant CCL17-dependent CCR4 activation alleviates neuroinflammation and neuronal apoptosis through the PI3K/AKT/Foxo1 signaling pathway after ICH in mice. J Neuroinflammation. 2021;18:62 pubmed publisher
Deng S, Sherchan P, Jin P, Huang L, Travis Z, Zhang J, et al. Recombinant CCL17 Enhances Hematoma Resolution and Activation of CCR4/ERK/Nrf2/CD163 Signaling Pathway After Intracerebral Hemorrhage in Mice. Neurotherapeutics. 2020;17:1940-1953 pubmed publisher
Palchevskiy V, Xue Y, Kern R, Weigt S, Gregson A, Song S, et al. CCR4 expression on host T cells is a driver for alloreactive responses and lung rejection. JCI Insight. 2019;5: pubmed publisher
He W, Holtkamp S, Hergenhan S, Kraus K, De Juan A, Weber J, et al. Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues. Immunity. 2018;49:1175-1190.e7 pubmed publisher
Rasheed K, Abdulsalam I, Fismen S, Grimstad Ø, Sveinbjørnsson B, Moens U. CCL17/TARC and CCR4 expression in Merkel cell carcinoma. Oncotarget. 2018;9:31432-31447 pubmed publisher
Kwon M, Shin H, Cui Y, Kim H, Thi A, Choi J, et al. CCL2 Mediates Neuron-Macrophage Interactions to Drive Proregenerative Macrophage Activation Following Preconditioning Injury. J Neurosci. 2015;35:15934-47 pubmed publisher
McMillin M, Frampton G, Thompson M, Galindo C, Standeford H, Whittington E, et al. Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J Neuroinflammation. 2014;11:121 pubmed publisher
product information
master code :
3581
SKU :
3581/10
product name :
C 021 dihydrochloride
unit size :
10 mg (also 50 mg)
description :
Potent CCR4 antagonist
target :
Chemokine Receptor Antagonists
category :
Small Molecules
purity :
99%
observed molecular weight :
540.57
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
C 021 dihydrochloride is a potent CCR4 chemokine receptor antagonist (IC50 values are 0.14 and 0.039 M for inhibition of chemotaxis in human and mouse respectively).
top caption :
Potent CCR4 antagonist
extended description :
Potent CCR4 antagonist
chemical name text :
2-[1,4 -Bipiperidin]-1 -yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine dihydrochloride
formula :
C27H41N5O2.2HCl
formula text :
C27H41N5O2.2HCl
cas num :
1784252-84-1
USD :
288 USD
product details :
Potent CCR4 antagonist
storage :
Desiccate at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK