HKI 357 | Tocris Bioscience 3580 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

HKI 357

catalog :

3580

quantity :

10 mg (also 50 mg)

price :

227 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

3580

SKU :

3580/10

product name :

HKI 357

description :

Dual irreversible inhibitor of ErbB2 and EGFR

target :

EGF Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

574.05

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent, irreversible inhibitor of ErbB2 (HER2) and EGFR (IC50 values are 33 and 34 nM respectively). Suppresses ligand-induced EGFR autophosphorylation and cell proliferation in NCI-H1975 cells containing L858R and T790M mutations. Circumvents mechanisms of resistance to Iressa (Cat. No. 3000) in non-small-cell lung cancer cells.

catalog number base :

3580

product keywords :

HKI357 EGFR epidermal growth factor receptors inhibitors inhibits irreversible dual potent ErbB2 HER2 EGFR 3580,

extended description :

Dual irreversible inhibitor of ErbB2 and EGFR

chemical name text :

(2E)-N-[[4-[[(3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide

formula :

C 31 H 29 ClFN 5 O 3

formula text :

C31H29ClFN5O3

cas num :

848133-17-5

2020 USD :

220

2021 USD :

227 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage