HKI 357 | Tocris Bioscience 3580/10 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

HKI 357

catalog :

3580/10

quantity :

10 mg (also 50 mg)

price :

263 USD

product information

brand :

Tocris

master code :

3580

SKU :

3580/10

product name :

HKI 357

description :

Dual irreversible inhibitor of ErbB2 and EGFR

target :

EGF Receptor Inhibitors

category :

Small Molecules

unit sizes :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

574.05

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

HKI 357 is a potent, irreversible inhibitor of ErbB2 (HER2) and EGFR (IC50 values are 33 and 34 nM respectively). Suppresses ligand-induced EGFR autophosphorylation and cell proliferation in NCI-H1975 cells containing L858R and T790M mutations. Circumvents mechanisms of resistance to Iressa (Cat. No. 3000) in non-small-cell lung cancer cells.

extended description :

Dual irreversible inhibitor of ErbB2 and EGFR

chemical name text :

(2E)-N-[[4-[[(3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide

formula :

C 31 H 29 ClFN 5 O 3

formula text :

C31H29ClFN5O3

cas num :

848133-17-5

USD :

263 USD

product details :

Dual irreversible inhibitor of ErbB2 and EGFR

storage :

Store at -20°C