5-BDBD | Tocris Bioscience 3579 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5-BDBD

catalog :

3579

quantity :

10 mg (also 50 mg)

price :

197 USD

more info or order :

Tocris Bioscience product webpage

citations: 17

Reference
Cruz A, Beall C. Extracellular ATP Increases Glucose Metabolism in Skeletal Muscle Cells in a P2 Receptor Dependent Manner but Does Not Contribute to Palmitate-Induced Insulin Resistance. Front Physiol. 2020;11:567378 pubmed publisher
Uderhardt S, Martins A, Tsang J, Lämmermann T, Germain R. Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell. 2019;177:541-555.e17 pubmed publisher
Zumerle S, Calì B, Munari F, Angioni R, Di Virgilio F, Molon B, et al. Intercellular Calcium Signaling Induced by ATP Potentiates Macrophage Phagocytosis. Cell Rep. 2019;27:1-10.e4 pubmed publisher
Dosch M, Zindel J, Jebbawi F, Melin N, Sánchez Taltavull D, Stroka D, et al. Connexin-43-dependent ATP release mediates macrophage activation during sepsis. elife. 2019;8: pubmed publisher
Dhuna K, Felgate M, Bidula S, Walpole S, Bibic L, Cromer B, et al. Ginsenosides Act As Positive Modulators of P2X4 Receptors. Mol Pharmacol. 2019;95:210-221 pubmed publisher
Gofman L, Fernandes N, Potula R. Relative Role of Akt, ERK and CREB in Alcohol-Induced Microglia P2X4R Receptor Expression. Alcohol Alcohol. 2016;51:647-654 pubmed
Chen H, Xia Q, Feng X, Cao F, Yu H, Song Y, et al. Effect of P2X4R on airway inflammation and airway remodeling in allergic airway challenge in mice. Mol Med Rep. 2016;13:697-704 pubmed publisher
Ledderose C, Bao Y, Ledderose S, Woehrle T, Heinisch M, Yip L, et al. Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense. J Infect Dis. 2016;213:456-64 pubmed publisher
Kawano A, Kadomatsu R, Ono M, Kojima S, Tsukimoto M, Sakamoto H. Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors. PLoS ONE. 2015;10:e0127919 pubmed publisher
Mascanfroni I, Takenaka M, Yeste A, Patel B, Wu Y, Kenison J, et al. Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-Î±. Nat Med. 2015;21:638-46 pubmed publisher
Maslieieva V, Thompson R. A critical role for pannexin-1 in activation of innate immune cells of the choroid plexus. Channels (Austin). 2014;8:131-41 pubmed publisher
Ilatovskaya D, Palygin O, Levchenko V, Staruschenko A. Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli. Am J Physiol Cell Physiol. 2013;305:C1050-9 pubmed publisher
Shabir S, Cross W, Kirkwood L, Pearson J, Appleby P, Walker D, et al. Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. Am J Physiol Renal Physiol. 2013;305:F396-406 pubmed publisher
Vergani A, Tezza S, D Addio F, Fotino C, Liu K, Niewczas M, et al. Long-term heart transplant survival by targeting the ionotropic purinergic receptor P2X7. Circulation. 2013;127:463-75 pubmed publisher
Trabanelli S, Ocadlikova D, Gulinelli S, Curti A, Salvestrini V, Vieira R, et al. Extracellular ATP exerts opposite effects on activated and regulatory CD4+ T cells via purinergic P2 receptor activation. J Immunol. 2012;189:1303-10 pubmed publisher
Nörenberg W, Sobottka H, Hempel C, Plötz T, Fischer W, Schmalzing G, et al. Positive allosteric modulation by ivermectin of human but not murine P2X7 receptors. Br J Pharmacol. 2012;167:48-66 pubmed publisher
Wu T, Dai M, Shi X, Jiang Z, Nuttall A. Functional expression of P2X4 receptor in capillary endothelial cells of the cochlear spiral ligament and its role in regulating the capillary diameter. Am J Physiol Heart Circ Physiol. 2011;301:H69-78 pubmed publisher

product information

brand :

Tocris

master code :

3579

SKU :

3579/10

product name :

5-BDBD

description :

Potent and selective P2X4 antagonist

target :

P2X Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

355.19

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective P2X4 receptor antagonist. Blocks P2X4-mediated currents in Chinese hamster ovary cells (IC50 = 0.50 M). Exhibits no significant antagonist effects at other P2X receptors. Reduces long-term potentiation (LTP) in rat hippocampal slices.

catalog number base :

3579

product keywords :

potent P2X4 antagonists purinergic receptors BDBD selective P2X Receptors 3579,

extended description :

Potent and selective P2X4 antagonist

chemical name text :

5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one

formula :

C 17 H 11 BrN 2 O 2

formula text :

C17H11BrN2O2

cas num :

768404-03-1

2020 USD :

187

2021 USD :

197 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage