AS 605240 | Tocris Bioscience 3578 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AS 605240

catalog :

3578

quantity :

10 mg (also 50 mg)

price :

169 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Schepetkin I, Kirpotina L, Khlebnikov A, Hanks T, Kochetkova I, Pascual D, et al. Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol Pharmacol. 2012;81:832-45 pubmed publisher
Beauséjour M, Noël D, Thibodeau S, Bouchard V, Harnois C, Beaulieu J, et al. Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes. Apoptosis. 2012;17:566-78 pubmed publisher

product information

brand :

Tocris

master code :

3578

SKU :

3578/10

product name :

AS 605240

description :

Potent and selective PI 3-kinase (PI 3-K ) inhibitor

target :

PI 3-Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

257.27

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective inhibitor of PI 3-kinase (PI 3-K ) (IC50 = 8 nM). Displays 30-fold selectivity over PI 3-K and PI 3-K and 7.5-fold selectivity over PI 3-K . Suppresses the progression of joint inflammation and damage in both lymphocyte-independent and lymphocyte-dependent mouse models of rheumatoid arthritis. Orally active and ATP-competitive.

catalog number base :

3578

product keywords :

AS605240 PI3Kgamma PI3K PI 3-kinasegamma 3-kinaseg 3-kinase phosphoinositide 3 kinases gamma Potent selective inhibitors inhibits inositol lipids signalling signaling orally active ATP-competitive PI 3-Kinase Inositol Lipids 3578,

extended description :

Potent and selective PI 3-kinase (PI 3-K ) inhibitor

chemical name text :

5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione

formula :

C 12 H 7 N 3 O 2 S

formula text :

C12H7N3O2S

cas num :

648450-29-7

2020 USD :

164

2021 USD :

169 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage