SB 612111 hydrochloride | Tocris Bioscience 3573/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SB 612111 hydrochloride

catalog :

3573/10

quantity :

10 mg (also 50 mg)

price :

346 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Mann A, Mouledous L, Froment C, O Neill P, Dasgupta P, Gunther T, et al. Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists. Sci Signal. 2019;12: pubmed publisher
Hardaway J, Jensen J, Kim M, Mazzone C, Sugam J, Diberto J, et al. Nociceptin receptor antagonist SB 612111 decreases high fat diet binge eating. Behav Brain Res. 2016;307:25-34 pubmed publisher
Parsons M, Burt J, Cranford A, Alberto C, Zipperlen K, Hirasawa M. Nociceptin induces hypophagia in the perifornical and lateral hypothalamic area. PLoS ONE. 2012;7:e45350 pubmed publisher

product information

brand :

Tocris

master code :

3573

SKU :

3573/10

product name :

SB 612111 hydrochloride

unit size :

10 mg (also 50 mg)

seo description :

Selective NOP antagonist

target :

NOP Receptor Antagonists

category :

Small Molecules

purity :

97%

observed molecular weight :

454.86

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SB 612111 hydrochloride is a selective NOP receptor antagonist (Ki values are 0.33, 57.6, 160.5 and 2109 nM for NOP, -, - and -receptors respectively). Antagonizes the pronociceptive action of nociceptin (Cat. No. 0910) in an acute pain model. Potentiates the action of morphine in morphine-tolerant animals and blocks hyperalgesia in an inflammatory pain model.

top caption :

Selective NOP antagonist

extended description :

Selective NOP antagonist

chemical name text :

(5S,7S)-7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-ol hydrochloride

formula :

C24H29Cl2NO.HCl

formula text :

C24H29Cl2NO.HCl

USD :

346 USD

product details :

Selective NOP antagonist

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage