GSK 650394 | Tocris Bioscience 3572 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GSK 650394

catalog :

3572

quantity :

10 mg (also 50 mg)

price :

229 USD

more info or order :

Tocris Bioscience product webpage

citations: 17

Reference
Messerschmidt L, Fischer S, Wiedemann P, Bringmann A, Hollborn M. Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation. Mol Vis. 2019;25:329-344 pubmed
Kleiner J, Hollborn M, Wiedemann P, Bringmann A. Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells. Mol Vis. 2018;24:647-666 pubmed
Bossmann M, Ackermann B, Thome U, Laube M. Signaling Cascade Involved in Rapid Stimulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Dexamethasone. Int J Mol Sci. 2017;18: pubmed publisher
Juvekar A, Hu H, Yadegarynia S, Lyssiotis C, Ullas S, Lien E, et al. Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion. Proc Natl Acad Sci U S A. 2016;113:E4338-47 pubmed publisher
Matschke J, Wiebeck E, Hurst S, Rudner J, Jendrossek V. Role of SGK1 for fatty acid uptake, cell survival and radioresistance of NCI-H460 lung cancer cells exposed to acute or chronic cycling severe hypoxia. Radiat Oncol. 2016;11:75 pubmed publisher
Zhang T, Fang S, Wan C, Kong Q, Wang G, Wang S, et al. Excess salt exacerbates blood-brain barrier disruption via a p38/MAPK/SGK1-dependent pathway in permanent cerebral ischemia. Sci Rep. 2015;5:16548 pubmed publisher
Hernandez A, Kitz A, Wu C, Lowther D, Rodriguez D, Vudattu N, et al. Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells. J Clin Invest. 2015;125:4212-22 pubmed publisher
Pastore D, Della Morte D, Coppola A, Capuani B, Lombardo M, Pacifici F, et al. SGK-1 protects kidney cells against apoptosis induced by ceramide and TNF-Î±. Cell Death Dis. 2015;6:e1890 pubmed publisher
Beauchamp R, James M, DeSouza P, Wagh V, Zhao W, Jordan J, et al. A high-throughput kinome screen reveals serum/glucocorticoid-regulated kinase 1 as a therapeutic target for NF2-deficient meningiomas. Oncotarget. 2015;6:16981-97 pubmed
Shin S, Lee E, Chun J, Hyun S, Kang S. Phosphorylation on TRPV4 Serine 824 Regulates Interaction with STIM1. Open Biochem J. 2015;9:24-33 pubmed publisher
Koeppen K, Coutermarsh B, Madden D, Stanton B. Serum- and glucocorticoid-induced protein kinase 1 (SGK1) increases the cystic fibrosis transmembrane conductance regulator (CFTR) in airway epithelial cells by phosphorylating Shank2E protein. J Biol Chem. 2014;289:17142-50 pubmed publisher
Mattes C, Laube M, Thome U. Rapid elevation of sodium transport through insulin is mediated by AKT in alveolar cells. Physiol Rep. 2014;2:e00269 pubmed publisher
Burgon J, Robertson A, Sadiku P, Wang X, Hooper Greenhill E, Prince L, et al. Serum and glucocorticoid-regulated kinase 1 regulates neutrophil clearance during inflammation resolution. J Immunol. 2014;192:1796-805 pubmed publisher
Andersen M, Krzystanek K, Petersen F, Bomholtz S, Olesen S, Abriel H, et al. A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein. J Biol Chem. 2013;288:36841-54 pubmed publisher
Peng H, Chen G, Lai C, Hsieh M, Lin T. Spinal serum-inducible and glucocorticoid-inducible kinase 1 mediates neuropathic pain via kalirin and downstream PSD-95-dependent NR2B phosphorylation in rats. J Neurosci. 2013;33:5227-40 pubmed publisher
Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker R, et al. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature. 2013;496:518-22 pubmed publisher
Kaiser G, Gerst F, Michael D, Berchtold S, Friedrich B, Strutz Seebohm N, et al. Regulation of forkhead box O1 (FOXO1) by protein kinase B and glucocorticoids: different mechanisms of induction of beta cell death in vitro. Diabetologia. 2013;56:1587-95 pubmed publisher

product information

brand :

Tocris

master code :

3572

SKU :

3572/10

product name :

GSK 650394

description :

Serum- and glucocorticoid-regulated kinase (SGK) inhibitor

target :

Other Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

97%

observed molecular weight :

382.45

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Serum- and glucocorticoid-regulated kinase 1 (SGK1) inhibitor (IC50 values are 62 and 103 nM for SGK1 and SGK2 respectively). Displays 30-fold selectivity over Akt and other related kinases. Inhibits androgen-stimulated growth of LNCaP cells, a human prostate carcinoma cell line (IC50 ~ 1 M).

catalog number base :

3572

product keywords :

Serum- glucocorticoid-regulated kinase SGK1 inhibitors inhibits androgen receptors GSK650394 GlaxoSmithKline GSK Other Kinases Androgen Receptor 3572,

extended description :

Serum- and glucocorticoid-regulated kinase (SGK) inhibitor

chemical name text :

2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoic acid

formula :

C 25 H 22 N 2 O 2

formula text :

C25H22N2O2

cas num :

890842-28-1

2020 USD :

220

2021 USD :

229 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage