product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
GSK 650394
catalog :
3572/10
quantity :
10 mg (also 50 mg)
price :
296 USD
more info or order :
citations: 33
Reference
Pennington K, McEwan C, Woods J, Muir C, Pramoda Sahankumari A, Eastmond R, et al. SGK2, 14-3-3, and HUWE1 Cooperate to Control the Localization, Stability, and Function of the Oncoprotein PTOV1. Mol Cancer Res. 2022;20:231-243 pubmed publisher
Ranzuglia V, Lorenzon I, Pellarin I, Sonego M, Dall Acqua A, D Andrea S, et al. Serum- and glucocorticoid- inducible kinase 2, SGK2, is a novel autophagy regulator and modulates platinum drugs response in cancer cells. Oncogene. 2020;39:6370-6386 pubmed publisher
Koundouros N, Karali E, Tripp A, Valle A, Inglese P, Perry N, et al. Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids. Cell. 2020;181:1596-1611.e27 pubmed publisher
Harachi M, Masui K, Honda H, Muragaki Y, Kawamata T, Cavenee W, et al. Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM. Mol Cancer Res. 2020;: pubmed publisher
Yang Y, Istomine R, Alvarez F, Al Aubodah T, Shi X, Takano T, et al. Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3+ Regulatory T Cells. Cell Rep. 2020;30:1515-1529.e4 pubmed publisher
Ito H, Watari K, Shibata T, Miyamoto T, Murakami Y, Nakahara Y, et al. Bidirectional Regulation between NDRG1 and GSK3β Controls Tumor Growth and Is Targeted by Differentiation Inducing Factor-1 in Glioblastoma. Cancer Res. 2020;80:234-248 pubmed publisher
Masui K, Harachi M, Ikegami S, Yang H, Onizuka H, Yong W, et al. mTORC2 links growth factor signaling with epigenetic regulation of iron metabolism in glioblastoma. J Biol Chem. 2019;294:19740-19751 pubmed publisher
Messerschmidt L, Fischer S, Wiedemann P, Bringmann A, Hollborn M. Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation. Mol Vis. 2019;25:329-344 pubmed
Hira S, Packialakshmi B, Zhou X. EAE-induced upregulation of mitochondrial MnSOD is associated with increases of mitochondrial SGK1 and Tom20 protein in the mouse kidney cortex. J Physiol Sci. 2019;: pubmed publisher
Villoslada P, Vila G, Colafrancesco V, Moreno B, Fernandez Diez B, Vázquez R, et al. Axonal and Myelin Neuroprotection by the Peptoid BN201 in Brain Inflammation. Neurotherapeutics. 2019;: pubmed publisher
Kleiner J, Hollborn M, Wiedemann P, Bringmann A. Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells. Mol Vis. 2018;24:647-666 pubmed
He L, Kulesskiy E, Saarela J, Turunen L, Wennerberg K, Aittokallio T, et al. Methods for High-throughput Drug Combination Screening and Synergy Scoring. Methods Mol Biol. 2018;1711:351-398 pubmed publisher
Stepanova V, Dergilev K, Holman K, Parfyonova Y, Tsokolaeva Z, Teter M, et al. Urokinase-type plasminogen activator (uPA) is critical for progression of tuberous sclerosis complex 2 (TSC2)-deficient tumors. J Biol Chem. 2017;292:20528-20543 pubmed publisher
Bossmann M, Ackermann B, Thome U, Laube M. Signaling Cascade Involved in Rapid Stimulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Dexamethasone. Int J Mol Sci. 2017;18: pubmed publisher
Tubbs A, Liu B, Rogers T, Sartor R, Miao E. Dietary Salt Exacerbates Experimental Colitis. J Immunol. 2017;199:1051-1059 pubmed publisher
Juvekar A, Hu H, Yadegarynia S, Lyssiotis C, Ullas S, Lien E, et al. Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion. Proc Natl Acad Sci U S A. 2016;113:E4338-47 pubmed publisher
Kook I, Jones C. The serum and glucocorticoid-regulated protein kinases (SGK) stimulate bovine herpesvirus 1 and herpes simplex virus 1 productive infection. Virus Res. 2016;222:106-112 pubmed publisher
Matschke J, Wiebeck E, Hurst S, Rudner J, Jendrossek V. Role of SGK1 for fatty acid uptake, cell survival and radioresistance of NCI-H460 lung cancer cells exposed to acute or chronic cycling severe hypoxia. Radiat Oncol. 2016;11:75 pubmed publisher
Zhang T, Fang S, Wan C, Kong Q, Wang G, Wang S, et al. Excess salt exacerbates blood-brain barrier disruption via a p38/MAPK/SGK1-dependent pathway in permanent cerebral ischemia. Sci Rep. 2015;5:16548 pubmed publisher
Hernandez A, Kitz A, Wu C, Lowther D, Rodriguez D, Vudattu N, et al. Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells. J Clin Invest. 2015;125:4212-22 pubmed publisher
Pastore D, Della Morte D, Coppola A, Capuani B, Lombardo M, Pacifici F, et al. SGK-1 protects kidney cells against apoptosis induced by ceramide and TNF-α. Cell Death Dis. 2015;6:e1890 pubmed publisher
Beauchamp R, James M, DeSouza P, Wagh V, Zhao W, Jordan J, et al. A high-throughput kinome screen reveals serum/glucocorticoid-regulated kinase 1 as a therapeutic target for NF2-deficient meningiomas. Oncotarget. 2015;6:16981-97 pubmed
Shin S, Lee E, Chun J, Hyun S, Kang S. Phosphorylation on TRPV4 Serine 824 Regulates Interaction with STIM1. Open Biochem J. 2015;9:24-33 pubmed publisher
Caohuy H, Yang Q, Eudy Y, Ha T, Xu A, Glover M, et al. Activation of 3-phosphoinositide-dependent kinase 1 (PDK1) and serum- and glucocorticoid-induced protein kinase 1 (SGK1) by short-chain sphingolipid C4-ceramide rescues the trafficking defect of ΔF508-cystic fibrosis transmembrane conductance regulat. J Biol Chem. 2014;289:35953-68 pubmed publisher
Koeppen K, Coutermarsh B, Madden D, Stanton B. Serum- and glucocorticoid-induced protein kinase 1 (SGK1) increases the cystic fibrosis transmembrane conductance regulator (CFTR) in airway epithelial cells by phosphorylating Shank2E protein. J Biol Chem. 2014;289:17142-50 pubmed publisher
Mattes C, Laube M, Thome U. Rapid elevation of sodium transport through insulin is mediated by AKT in alveolar cells. Physiol Rep. 2014;2:e00269 pubmed publisher
Robertson A, Holmes G, Bojarczuk A, Burgon J, Loynes C, Chimen M, et al. A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism. Sci Transl Med. 2014;6:225ra29 pubmed publisher
Burgon J, Robertson A, Sadiku P, Wang X, Hooper Greenhill E, Prince L, et al. Serum and glucocorticoid-regulated kinase 1 regulates neutrophil clearance during inflammation resolution. J Immunol. 2014;192:1796-805 pubmed publisher
Elloul S, Kedrin D, Knoblauch N, Beck A, Toker A. The adherens junction protein afadin is an AKT substrate that regulates breast cancer cell migration. Mol Cancer Res. 2014;12:464-76 pubmed publisher
Andersen M, Krzystanek K, Petersen F, Bomholtz S, Olesen S, Abriel H, et al. A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein. J Biol Chem. 2013;288:36841-54 pubmed publisher
Peng H, Chen G, Lai C, Hsieh M, Lin T. Spinal serum-inducible and glucocorticoid-inducible kinase 1 mediates neuropathic pain via kalirin and downstream PSD-95-dependent NR2B phosphorylation in rats. J Neurosci. 2013;33:5227-40 pubmed publisher
Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker R, et al. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature. 2013;496:518-22 pubmed publisher
Kaiser G, Gerst F, Michael D, Berchtold S, Friedrich B, Strutz Seebohm N, et al. Regulation of forkhead box O1 (FOXO1) by protein kinase B and glucocorticoids: different mechanisms of induction of beta cell death in vitro. Diabetologia. 2013;56:1587-95 pubmed publisher
product information
brand :
Tocris
master code :
3572
SKU :
3572/10
product name :
GSK 650394
unit size :
10 mg (also 50 mg)
seo description :
Serum- and glucocorticoid-regulated kinase (SGK) inhibitor
target :
Other Kinase Inhibitors
category :
Small Molecules
purity :
97%
observed molecular weight :
382.45
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
GSK 650394 is a serum- and glucocorticoid-regulated kinase 1 (SGK1) inhibitor (IC50 values are 62 and 103 nM for SGK1 and SGK2 respectively). Displays 30-fold selectivity over Akt and other related kinases. Inhibits androgen-stimulated growth of LNCaP cells, a human prostate carcinoma cell line (IC50 ~ 1 M).
top caption :
Serum- and glucocorticoid-regulated kinase (SGK) inhibitor
extended description :
Serum- and glucocorticoid-regulated kinase (SGK) inhibitor
chemical name text :
2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoic acid
formula :
C25H22N2O2
formula text :
C25H22N2O2
cas num :
890842-28-1
USD :
296 USD
product details :
Serum- and glucocorticoid-regulated kinase (SGK) inhibitor
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK