Z-Guggulsterone | Tocris Bioscience 3570/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Z-Guggulsterone

catalog :

3570/10

quantity :

10 mg (also 50 mg)

price :

251 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Liu T, Kern J, Jain U, Sonnek N, Xiong S, Simpson K, et al. Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation. Cell Host Microbe. 2021;29:988-1001.e6 pubmed publisher
Ng K, Chai S, Tong M, Guan X, Lin C, Ching Y, et al. C-terminal truncated hepatitis B virus X protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like properties. Oncotarget. 2016;7:24005-17 pubmed publisher

product information

brand :

Tocris

master code :

3570

SKU :

3570/10

product name :

Z-Guggulsterone

unit size :

10 mg (also 50 mg)

seo description :

Broad spectrum steroid receptor ligand. More active isomer of guggulsterone (Cat. No. 2013)

target :

Additional Nuclear Receptor Compounds

category :

Small Molecules

purity :

98%

observed molecular weight :

312.45

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Z -Guggulsterone is a broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (Ki = 315 nM). Induces apoptosis in prostate cancer cells and inhibits angiogenesis via suppression of the VEGF-VEGFR2-Akt signaling pathway. Exhibits antilipidemic activity via antagonism of the farnesoid X receptor (FXR) and displays antiseptic, antirheumatic and anti-inflammatory activity in vivo . More active isomer of guggulsterone (Cat. No. 2013).

top caption :

Broad spectrum steroid receptor ligand. More active isomer of guggulsterone (Cat. No. 2013)

extended description :

Broad spectrum steroid receptor ligand. More active isomer of guggulsterone (Cat. No. 2013)

chemical name text :

(Z)-Pregna-4,17(20)-diene-3,16-dione

formula :

C21H28O2

formula text :

C21H28O2

cas num :

39025-23-5

USD :

251 USD

product details :

Broad spectrum steroid receptor ligand. More active isomer of guggulsterone (Cat. No. 2013)

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage