Xanomeline oxalate | Tocris Bioscience 3569/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Xanomeline oxalate

catalog :

3569/10

quantity :

10 mg (also 50 mg)

price :

254 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Galvin V, Yang S, Paspalas C, Yang Y, Jin L, Datta D, et al. Muscarinic M1 Receptors Modulate Working Memory Performance and Activity via KCNQ Potassium Channels in the Primate Prefrontal Cortex. Neuron. 2020;106:649-661.e4 pubmed publisher
Tian M, Xu J, Lei G, Lombroso P, Jackson M, MacDonald J. STEP activation by G?q coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit. Sci Rep. 2016;6:36684 pubmed publisher
Gu L, Li C, Aach J, Hill D, Vidal M, Church G. Multiplex single-molecule interaction profiling of DNA-barcoded proteins. Nature. 2014;515:554-7 pubmed publisher

product information

brand :

Tocris

master code :

3569

SKU :

3569/10

product name :

Xanomeline oxalate

unit size :

10 mg (also 50 mg)

seo description :

Functionally biased muscarinic M4 receptor agonist

target :

mAChR M1 Agonists

category :

Small Molecules

purity :

98%

observed molecular weight :

371.46

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Xanomeline oxalate is a functionally biased muscarinic M4 receptor agonist (EC50 values are 14.1 nM, 30.9 nM, 1700 nM, 1800 nM and 8500 nM at M4, M1, M2, M5 and M3 receptors respectively. Binds with similar affinity to all muscarinic acetylcholine receptors (pKi 6.7-7.7) but displays higher efficacy and efficacy-driven selectivity at M4 receptors. Displays a complex pharmacological profile: reversible and wash-resistant binding, resulting in full agonist activity at M1; delayed wash-resistant partial agonist activity at M2; and delayed wash-resistant full agonist activity at M4. Exhibits antipsychotic activity, and improves cognitive deficits and behavioral disturbances in Alzheimer s disease and schizophrenia.

top caption :

Functionally biased muscarinic M4 receptor agonist

extended description :

Functionally biased muscarinic M4 receptor agonist

chemical name text :

3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridine oxalate

formula :

C14H23N3OS.C2H2O4

formula text :

C14H23N3OS.C2H2O4

cas num :

141064-23-5

USD :

254 USD

product details :

Functionally biased muscarinic M4 receptor agonist

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage