chemical

ONO AE3 208

3565

10 mg (also 50 mg)

223 USD

3565

3565/10

ONO AE3 208

High affinity and selective EP4 antagonist

Prostanoid Receptor Antagonists

Small Molecules

10 mg (also 50 mg)

98%

404.43

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High affinity and selective EP4 receptor antagonist (Ki values are 1.3, 30, 790 and 2400 nM for EP4, EP3, FP and TP receptors respectively). Displays no affinity for EP1, EP2, DP or IP receptors (Ki 10 M). Inhibits PGE2-induced IL-8 production in colonic epithelial caco-2 cells and attenuates PGE2 inhibition of natural killer T cell activation. Suppresses recovery from experimentally-induced colitis and stimulates CD4+ T cell proliferation in C57BL/6 mice. Also reduces metastasis of mammary tumor cells in a murine model of breast cancer. Orally active.

3565

ONOAE3208 selective EP4 receptors antagonists prostanoids PGE2 prostaglandins high affinity orally active prostanoids Prostanoid Receptors 3565,

High affinity and selective EP4 antagonist

4-Cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]benzenebutanoic acid

C 24 H 21 FN 2 O 3

C24H21FN2O3

402473-54-5

214

223 USD

Store at -20°C