ONO AE3 208 | Tocris Bioscience 3565/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ONO AE3 208

catalog :

3565/10

quantity :

10 mg (also 50 mg)

price :

281 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Bin N, Prescott S, Horio N, Wang Y, Chiu I, Liberles S. An airway-to-brain sensory pathway mediates influenza-induced sickness. Nature. 2023;615:660-667 pubmed publisher
Hamidzadeh K, Belew A, El Sayed N, Mosser D. The transition of M-CSF-derived human macrophages to a growth-promoting phenotype. Blood Adv. 2020;4:5460-5472 pubmed publisher

product information

brand :

Tocris

master code :

3565

SKU :

3565/10

product name :

ONO AE3 208

unit size :

10 mg (also 50 mg)

seo description :

High affinity and selective EP4 antagonist

target :

Prostanoid Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

404.43

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ONO AE3 208 is a high affinity and selective EP4 receptor antagonist (Ki values are 1.3, 30, 790 and 2400 nM for EP4, EP3, FP and TP receptors respectively). Displays no affinity for EP1, EP2, DP or IP receptors (Ki 10 M). Inhibits PGE2-induced IL-8 production in colonic epithelial caco-2 cells and attenuates PGE2 inhibition of natural killer T cell activation. Suppresses recovery from experimentally-induced colitis and stimulates CD4+ T cell proliferation in C57BL/6 mice. Also reduces metastasis of mammary tumor cells in a murine model of breast cancer. Orally active.

top caption :

High affinity and selective EP4 antagonist

extended description :

High affinity and selective EP4 antagonist

chemical name text :

4-Cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]benzenebutanoic acid

formula :

C24H21FN2O3

formula text :

C24H21FN2O3

cas num :

402473-54-5

USD :

281 USD

product details :

High affinity and selective EP4 antagonist

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage