L189 | Tocris Bioscience 3561/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

L189

catalog :

3561/10

quantity :

10 mg

price :

225 USD

citations: 2

Reference
Vartak S, Swarup H, Gopalakrishnan V, Gopinatha V, Ropars V, Nambiar M, et al. Autocyclized and oxidized forms of SCR7 induce cancer cell death by inhibiting nonhomologous DNA end joining in a Ligase IV dependent manner. FEBS J. 2018;285:3959-3976 pubmed publisher
Chen X, Zhong S, Zhu X, Dziegielewska B, Ellenberger T, Wilson G, et al. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 2008;68:3169-77 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

3561

SKU :

3561/10

product name :

L189

Description :

DNA ligase I, III and IV inhibitor

target :

DNA Ligase Inhibitors

category :

Small Molecules

unit size :

10 mg

observed molecular weight :

246.29

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

L189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 M respectively) that blocks DNA binding (Ki = 5 M for DNA ligase I). Preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ). Specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents.

extended description :

DNA ligase I, III and IV inhibitor

chemical name text :

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone

formula :

C 11 H 10 N 4 OS

formula text :

C11H10N4OS

cas num :

64232-83-3

USD :

225 USD

product details :

DNA ligase I, III and IV inhibitor

storage :

Store at -20°C