product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
(-)-Nicotine ditartrate
catalog :
3546/50
quantity :
50 mg
price :
100 USD
more info or order :
citations: 12
Reference
Maddux J, Gonzales L, Kregar N. β2* nicotinic acetylcholine receptor subtypes mediate nicotine-induced enhancement of Pavlovian conditioned responding to an alcohol cue. Front Behav Neurosci. 2022;16:1004368 pubmed publisher
Zaniewska M, Nikiforuk A, G x142 owacka U, Brygider S, Weso x142 owska J, Litwa E, et al. Chronic Lorcaserin Treatment Reverses the Nicotine Withdrawal-Induced Disruptions to Behavior and Maturation in Developing Neurons in the Hippocampus of Rats. Int J Mol Sci. 2021;22: pubmed publisher
Dorst M, Tokarska A, Zhou M, Lee K, Stagkourakis S, Broberger C, et al. Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner. Nat Commun. 2020;11:5113 pubmed publisher
Kweon H, Gu S, Witham E, Dhara M, Yu H, Mandon E, et al. NACHO Engages N-Glycosylation ER Chaperone Pathways for α7 Nicotinic Receptor Assembly. Cell Rep. 2020;32:108025 pubmed publisher
Weir K, Dupré C, van Giesen L, Lee A, Bellono N. A molecular filter for the cnidarian stinging response. elife. 2020;9: pubmed publisher
Gu S, MATTA J, Davini W, Dawe G, Lord B, Bredt D. α6-Containing Nicotinic Acetylcholine Receptor Reconstitution Involves Mechanistically Distinct Accessory Components. Cell Rep. 2019;26:866-874.e3 pubmed publisher
Tanimura A, Du Y, Kondapalli J, Wokosin D, Surmeier D. Cholinergic Interneurons Amplify Thalamostriatal Excitation of Striatal Indirect Pathway Neurons in Parkinson's Disease Models. Neuron. 2019;101:444-458.e6 pubmed publisher
Garcia Bereguiain M, Gonzalez Islas C, Lindsly C, Wenner P. Spontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo. J Neurosci. 2016;36:7268-82 pubmed publisher
Chalabi Yani D, Sahraei H, Meftahi G, Hosseini S, Sadeghi Gharajehdaghi S, Ali Beig H, et al. Effect of Transient Inactivation of Ventral Tegmental Area on the Expression and Acquisition of Nicotine-Induced Conditioned Place Preference in Rats. Iran Biomed J. 2015;19:214-9 pubmed
Tang J, Xie B, Bian X, Xue Y, Wei N, Zhou J, et al. Identification and in vitro pharmacological characterization of a novel and selective α7 nicotinic acetylcholine receptor agonist, Br-IQ17B. Acta Pharmacol Sin. 2015;36:800-12 pubmed publisher
Leao R, Mikulovic S, Leao K, Munguba H, Gezelius H, Enjin A, et al. OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons. Nat Neurosci. 2012;15:1524-30 pubmed publisher
Owaisat S, Raffa R, Rawls S. In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism. Neurosci Lett. 2012;525:12-6 pubmed publisher
product information
brand :
Tocris
master code :
3546
SKU :
3546/50
product name :
(-)-Nicotine ditartrate
unit size :
50 mg
seo description :
Prototypical nAChR agonist
target :
Additional Nicotinic Receptor Agonists
category :
Small Molecules
purity :
99%
observed molecular weight :
462.41
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
(-)-Nicotine ditartrate is a nicotinic acetylcholine receptor (nAChR) agonist (Ki values are 1, 1000, 4000 and 7130 nM at 4 2, 1 1 , rat 7 and human 7 respectively). Exhibits vasoconstrictive, hypertensive and prothrombotic activity in vivo .
top caption :
Prototypical nAChR agonist
extended description :
Prototypical nAChR agonist
chemical name text :
(S)-(-)-1-Methyl-2-(3-pyridyl)pyrrolidine (+)-ditartrate salt
formula :
C10H14N2.2C4H6O6
formula text :
C10H14N2.2C4H6O6
cas num :
65-31-6
USD :
100 USD
product details :
Prototypical nAChR agonist
storage :
Desiccate at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK