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company name :
Tocris Bioscience
product type :
chemical
product name :
KU 55933
catalog :
3544/10
quantity :
10 mg
price :
292 USD
more info or order :
citations: 103
Reference
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Balmus G, Pilger D, Coates J, Demir M, Sczaniecka Clift M, Barros A, et al. ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks. Nat Commun. 2019;10:87 pubmed publisher
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Gautam D, Johnson B, Mac M, Moody C. SETD2-dependent H3K36me3 plays a critical role in epigenetic regulation of the HPV31 life cycle. PLoS Pathog. 2018;14:e1007367 pubmed publisher
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Hernandez C, Wang Z, Ramazanov B, Tang Y, Mehta S, Dambrot C, et al. Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency. Cell Stem Cell. 2018;23:396-411.e8 pubmed publisher
Kim S, Nair D, Romero M, Serna V, Koleske A, Woodruff T, et al. Transient inhibition of p53 homologs protects ovarian function from two distinct apoptotic pathways triggered by anticancer therapies. Cell Death Differ. 2019;26:502-515 pubmed publisher
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Edwards T, Bloom D, Fisher C. The ATM and Rad3-Related (ATR) Protein Kinase Pathway Is Activated by Herpes Simplex Virus 1 and Required for Efficient Viral Replication. J Virol. 2018;92: pubmed publisher
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Jaiswal H, Benada J, Müllers E, Akopyan K, Burdova K, Koolmeister T, et al. ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration. EMBO J. 2017;36:2161-2176 pubmed publisher
Wu Q, Allouch A, Paoletti A, Leteur C, Mirjolet C, Martins I, et al. NOX2-dependent ATM kinase activation dictates pro-inflammatory macrophage phenotype and improves effectiveness to radiation therapy. Cell Death Differ. 2017;24:1632-1644 pubmed publisher
Sastre Moreno G, Pryor J, Moreno Oñate M, Herrero Ruiz A, Cortés Ledesma F, Blanco L, et al. Regulation of human polλ by ATM-mediated phosphorylation during non-homologous end joining. DNA Repair (Amst). 2017;51:31-45 pubmed publisher
Tripathi E, Smith S. Cell cycle-regulated ubiquitination of tankyrase 1 by RNF8 and ABRO1/BRCC36 controls the timing of sister telomere resolution. EMBO J. 2017;36:503-519 pubmed publisher
Benkafadar N, Menardo J, Bourien J, Nouvian R, François F, Decaudin D, et al. Reversible p53 inhibition prevents cisplatin ototoxicity without blocking chemotherapeutic efficacy. EMBO Mol Med. 2017;9:7-26 pubmed publisher
Lambrus B, Daggubati V, Uetake Y, Scott P, Clutario K, Sluder G, et al. A USP28-53BP1-p53-p21 signaling axis arrests growth after centrosome loss or prolonged mitosis. J Cell Biol. 2016;214:143-53 pubmed publisher
Langlands H, Blain P, Jowsey P. Fe65 Is Phosphorylated on Ser289 after UV-Induced DNA Damage. PLoS ONE. 2016;11:e0155056 pubmed publisher
Acebes Huerta A, Lorenzo Herrero S, Folgueras A, Huergo Zapico L, Lopez Larrea C, Lopez Soto A, et al. Drug-induced hyperploidy stimulates an antitumor NK cell response mediated by NKG2D and DNAM-1 receptors. Oncoimmunology. 2016;5:e1074378 pubmed
Allen C, Tinganelli W, Sharma N, Nie J, Sicard C, Natale F, et al. DNA Damage Response Proteins and Oxygen Modulate Prostaglandin E2 Growth Factor Release in Response to Low and High LET Ionizing Radiation. Front Oncol. 2015;5:260 pubmed publisher
Liu N, Boohaker R, Jiang C, Boohaker J, Xu B. A radiosensitivity MiRNA signature validated by the TCGA database for head and neck squamous cell carcinomas. Oncotarget. 2015;6:34649-57 pubmed publisher
Okita R, Wolf D, Yasuda K, Maeda A, Yukawa T, Saisho S, et al. Contrasting Effects of the Cytotoxic Anticancer Drug Gemcitabine and the EGFR Tyrosine Kinase Inhibitor Gefitinib on NK Cell-Mediated Cytotoxicity via Regulation of NKG2D Ligand in Non-Small-Cell Lung Cancer Cells. PLoS ONE. 2015;10:e0139809 pubmed publisher
Ahmed S, Carruthers R, Gilmour L, Yildirim S, Watts C, Chalmers A. Selective Inhibition of Parallel DNA Damage Response Pathways Optimizes Radiosensitization of Glioblastoma Stem-like Cells. Cancer Res. 2015;75:4416-28 pubmed publisher
Malonia S, Dutta P, Santra M, Green M. F-box protein FBXO31 directs degradation of MDM2 to facilitate p53-mediated growth arrest following genotoxic stress. Proc Natl Acad Sci U S A. 2015;112:8632-7 pubmed publisher
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Colin D, Hain K, Allan L, Clarke P. Cellular responses to a prolonged delay in mitosis are determined by a DNA damage response controlled by Bcl-2 family proteins. Open Biol. 2015;5:140156 pubmed publisher
Beggs K, Maiuri A, Fullerton A, Poulsen K, Breier A, Ganey P, et al. Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-related. Toxicology. 2015;331:35-46 pubmed publisher
Weyemi U, Redon C, Aziz T, Choudhuri R, Maeda D, Parekh P, et al. NADPH oxidase 4 is a critical mediator in Ataxia telangiectasia disease. Proc Natl Acad Sci U S A. 2015;112:2121-6 pubmed publisher
Gibbs Seymour I, Markiewicz E, Bekker Jensen S, Mailand N, Hutchison C. Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage. Aging Cell. 2015;14:162-9 pubmed publisher
Rodgers W, Byrum J, Sapkota H, Rahman N, Cail R, Zhao S, et al. Spatio-temporal regulation of RAG2 following genotoxic stress. DNA Repair (Amst). 2015;27:19-27 pubmed publisher
von Stechow L, Typas D, Carreras Puigvert J, Oort L, Siddappa R, Pines A, et al. The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest. Mol Cell Biol. 2015;35:1254-68 pubmed publisher
Teng P, Bateman N, Darcy K, Hamilton C, Maxwell G, Bakkenist C, et al. Pharmacologic inhibition of ATR and ATM offers clinically important distinctions to enhancing platinum or radiation response in ovarian, endometrial, and cervical cancer cells. Gynecol Oncol. 2015;136:554-61 pubmed publisher
Henriksson S, Rassoolzadeh H, Hedström E, Coucoravas C, Julner A, Goldstein M, et al. The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair. Genes Dev. 2014;28:2726-38 pubmed publisher
Freije A, Molinuevo R, Ceballos L, Cagigas M, Alonso Lecue P, Rodriguez R, et al. Inactivation of p53 in Human Keratinocytes Leads to Squamous Differentiation and Shedding via Replication Stress and Mitotic Slippage. Cell Rep. 2014;9:1349-60 pubmed publisher
Wu R, Cao L, Chen B, Cheng W. Selenoprotein H suppresses cellular senescence through genome maintenance and redox regulation. J Biol Chem. 2014;289:34378-88 pubmed publisher
Chaudhary N, Nakka K, Chavali P, Bhat J, Chatterjee S, Chattopadhyay S. SMAR1 coordinates HDAC6-induced deacetylation of Ku70 and dictates cell fate upon irradiation. Cell Death Dis. 2014;5:e1447 pubmed publisher
Ye J, Ma C, Hsueh E, Dou J, Mo W, Liu S, et al. TLR8 signaling enhances tumor immunity by preventing tumor-induced T-cell senescence. EMBO Mol Med. 2014;6:1294-311 pubmed publisher
Sheng R, Zhang T, Felice V, Qin T, Qin Z, Smith C, et al. Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons. J Biol Chem. 2014;289:20845-57 pubmed
Bodakuntla S, Libi A, Sural S, Trivedi P, Lahiri M. N-nitroso-N-ethylurea activates DNA damage surveillance pathways and induces transformation in mammalian cells. BMC Cancer. 2014;14:287 pubmed publisher
Alvarez Quilón A, Serrano Benítez A, Lieberman J, Quintero C, Sánchez Gutiérrez D, Escudero L, et al. ATM specifically mediates repair of double-strand breaks with blocked DNA ends. Nat Commun. 2014;5:3347 pubmed publisher
Sakai H, Fujigaki H, Mazur S, Appella E. Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication. Cell Cycle. 2014;13:1015-29 pubmed publisher
Kim D, Suh E. Defying DNA double-strand break-induced death during prophase I meiosis by temporal TAp63α phosphorylation regulation in developing mouse oocytes. Mol Cell Biol. 2014;34:1460-73 pubmed publisher
Shi Y, Nikulenkov F, Zawacka Pankau J, Li H, Gabdoulline R, Xu J, et al. ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis. Cell Death Differ. 2014;21:612-23 pubmed publisher
Alekseev O, Donovan K, Azizkhan Clifford J. Inhibition of ataxia telangiectasia mutated (ATM) kinase suppresses herpes simplex virus type 1 (HSV-1) keratitis. Invest Ophthalmol Vis Sci. 2014;55:706-15 pubmed publisher
Shirazi Fard S, All Ericsson C, Hallböök F. The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway. Cell Cycle. 2014;13:408-17 pubmed publisher
Valero M, Cimas F, Arias L, Melgar Rojas P, Garcia E, Callejas Valera J, et al. E1a promotes c-Myc-dependent replicative stress: implications in glioblastoma radiosensitization. Cell Cycle. 2014;13:52-61 pubmed publisher
Leung W, Vong Q, Lin W, Janke L, Chen T, Leung W. Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXR? activation. J Exp Med. 2013;210:2675-92 pubmed publisher
Rulten S, Rotheray A, Green R, Grundy G, Moore D, Gómez Herreros F, et al. PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage. Nucleic Acids Res. 2014;42:307-14 pubmed publisher
Montané M, Menand B. ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change. J Exp Bot. 2013;64:4361-74 pubmed publisher
Britton S, Coates J, Jackson S. A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair. J Cell Biol. 2013;202:579-95 pubmed publisher
Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, et al. Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells. Endocr Relat Cancer. 2013;20:633-47 pubmed publisher
Lee B, Gapud E, Zhang S, Dorsett Y, Bredemeyer A, George R, et al. Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination. Mol Cell Biol. 2013;33:3568-79 pubmed publisher
Kumala S, Fujarewicz K, Jayaraju D, Rzeszowska Wolny J, Hancock R. Repair of DNA strand breaks in a minichromosome in vivo: kinetics, modeling, and effects of inhibitors. PLoS ONE. 2013;8:e52966 pubmed publisher
Luo Y, Deng X, Cheng F, Li Y, Qiu J. SMC1-mediated intra-S-phase arrest facilitates bocavirus DNA replication. J Virol. 2013;87:4017-32 pubmed publisher
Edwards T, Helmus M, Koeller K, Bashkin J, Fisher C. Human papillomavirus episome stability is reduced by aphidicolin and controlled by DNA damage response pathways. J Virol. 2013;87:3979-89 pubmed publisher
Oksenych V, Kumar V, Liu X, Guo C, Schwer B, Zha S, et al. Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining. Proc Natl Acad Sci U S A. 2013;110:2234-9 pubmed publisher
Lottersberger F, Bothmer A, Robbiani D, Nussenzweig M, de Lange T. Role of 53BP1 oligomerization in regulating double-strand break repair. Proc Natl Acad Sci U S A. 2013;110:2146-51 pubmed publisher
Bothmer A, Rommel P, Gazumyan A, Polato F, Reczek C, Muellenbeck M, et al. Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching. J Exp Med. 2013;210:115-23 pubmed publisher
Sultana R, Abdel Fatah T, Abbotts R, Hawkes C, Albarakati N, Seedhouse C, et al. Targeting XRCC1 deficiency in breast cancer for personalized therapy. Cancer Res. 2013;73:1621-34 pubmed publisher
Cataldi M, McCarty D. Hairpin-end conformation of adeno-associated virus genome determines interactions with DNA-repair pathways. Gene Ther. 2013;20:686-93 pubmed publisher
Yüce O, West S. Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response. Mol Cell Biol. 2013;33:406-17 pubmed publisher
Neumayer G, Helfricht A, Shim S, Le H, Lundin C, Belzil C, et al. Targeting protein for xenopus kinesin-like protein 2 (TPX2) regulates ?-histone 2AX (?-H2AX) levels upon ionizing radiation. J Biol Chem. 2012;287:42206-22 pubmed publisher
Mund A, Schubert T, Staege H, Kinkley S, Reumann K, Kriegs M, et al. SPOC1 modulates DNA repair by regulating key determinants of chromatin compaction and DNA damage response. Nucleic Acids Res. 2012;40:11363-79 pubmed publisher
Yamamoto K, Wang Y, Jiang W, Liu X, Dubois R, Lin C, et al. Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice. J Cell Biol. 2012;198:305-13 pubmed publisher
Ando K, Kernan J, Liu P, Sanda T, Logette E, Tschopp J, et al. PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling. Mol Cell. 2012;47:681-93 pubmed publisher
Sullivan K, Padilla Just N, Henry R, Porter C, Kim J, Tentler J, et al. ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53. Nat Chem Biol. 2012;8:646-54 pubmed publisher
Yuan J, Luo K, Liu T, Lou Z. Regulation of SIRT1 activity by genotoxic stress. Genes Dev. 2012;26:791-6 pubmed publisher
Fumagalli M, Rossiello F, Clerici M, Barozzi S, Cittaro D, Kaplunov J, et al. Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. Nat Cell Biol. 2012;14:355-65 pubmed publisher
Kumar S, Yoo H, Kumagai A, Shevchenko A, Shevchenko A, Dunphy W. Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts. Cell Cycle. 2012;11:1183-94 pubmed publisher
Richardson E, Stockwell S, Li H, Aherne W, Cuomo M, Mittnacht S. Mechanism-based screen establishes signalling framework for DNA damage-associated G1 checkpoint response. PLoS ONE. 2012;7:e31627 pubmed publisher
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product information
brand :
Tocris
master code :
3544
SKU :
3544/10
product name :
KU 55933
unit size :
10 mg
seo description :
Potent and selective ATM kinase inhibitor
target :
ATM and ATR Kinase Inhibitors
category :
Small Molecules
purity :
98%
observed molecular weight :
395.49
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
KU 55933 is a potent, selective and competitive ATM kinase inhibitor (Ki = 2.2 nM, IC50 values are 13, 2500, 9300, 16600, 100000 and 100000 nM at ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively). Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21CIP1 levels in vitro . Acts as a radio- and chemosensitizer for the treatment of cancer.
top caption :
Potent and selective ATM kinase inhibitor
extended description :
Potent and selective ATM kinase inhibitor
chemical name text :
2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one
formula :
C21H17NO3S2
formula text :
C21H17NO3S2
cas num :
587871-26-9
USD :
292 USD
product details :
Potent and selective ATM kinase inhibitor
storage :
Desiccate at -20░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK