Orlistat | Tocris Bioscience 3540/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Orlistat

catalog :

3540/10

quantity :

10 mg (also 50 mg)

price :

84 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Murata Y, Harada N, Kishino S, Iwasaki K, Ikeguchi Ogura E, Yamane S, et al. Medium-chain triglycerides inhibit long-chain triglyceride-induced GIP secretion through GPR120-dependent inhibition of CCK. iScience. 2021;24:102963 pubmed publisher
Argueta D, Perez P, Makriyannis A, DiPatrizio N. Cannabinoid CB1 Receptors Inhibit Gut-Brain Satiation Signaling in Diet-Induced Obesity. Front Physiol. 2019;10:704 pubmed publisher
Xiao L, Priest M, Kozorovitskiy Y. Oxytocin functions as a spatiotemporal filter for excitatory synaptic inputs to VTA dopamine neurons. elife. 2018;7: pubmed publisher
Musella A, Fresegna D, Rizzo F, Gentile A, Bullitta S, De Vito F, et al. A novel crosstalk within the endocannabinoid system controls GABA transmission in the striatum. Sci Rep. 2017;7:7363 pubmed publisher
Caiati M, Sivakumaran S, Lanore F, Mulle C, Richard E, Verrier D, et al. Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses. Sci Rep. 2012;2:285 pubmed publisher
Breunig E, Manzini I, Piscitelli F, Gutermann B, Di Marzo V, Schild D, et al. The endocannabinoid 2-arachidonoyl-glycerol controls odor sensitivity in larvae of Xenopus laevis. J Neurosci. 2010;30:8965-73 pubmed publisher

product information

brand :

Tocris

master code :

3540

SKU :

3540/10

product name :

Orlistat

unit size :

10 mg (also 50 mg)

seo description :

Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity

target :

Lipase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

495.73

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Orlistat is a hypolipemic pancreatic, gastric and carboxylester lipase inhibitor. Exhibits no activity at phospholipase A2, liver esterase, trypsin and chymotrypsin. Inhibits the thioesterase domain of fatty acid synthase, leading to cell cycle arrest at the G1/S boundary in vitro . Prevents the absorption of approximately one third of fat from food and exhibits progastrokinetic, antiobesity and antihypercholesterolemic activity in vivo . Orlistat inhibits neutral lipid lipase LIPE and dose-dependently reduces -synuclein-positive cytoplasmic inclusions in -synuclein-expressing neuroblastoma cell lines.

top caption :

Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity

extended description :

Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity

chemical name text :

N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester

formula :

C29H53NO5

formula text :

C29H53NO5

cas num :

96829-58-2

USD :

84 USD

product details :

Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage