Sivelestat sodium salt | Tocris Bioscience 3535 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Sivelestat sodium salt

catalog :

3535

quantity :

10 mg (also 50 mg)

price :

125 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
van den Berg M, MacCarthy Morrogh L, Carter D, Morris J, Ribeiro Bravo I, Feng Y, et al. Proteolytic and Opportunistic Breaching of the Basement Membrane Zone by Immune Cells during Tumor Initiation. Cell Rep. 2019;27:2837-2846.e4 pubmed publisher
Albrengues J, Shields M, Ng D, Park C, Ambrico A, Poindexter M, et al. Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science. 2018;361: pubmed publisher
Masood A, Yi M, Belcastro R, Li J, Lopez L, Kantores C, et al. Neutrophil elastase-induced elastin degradation mediates macrophage influx and lung injury in 60% O2-exposed neonatal rats. Am J Physiol Lung Cell Mol Physiol. 2015;309:L53-62 pubmed publisher
Saadoun S, Waters P, MacDonald C, Bell B, Vincent A, Verkman A, et al. Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain. Ann Neurol. 2012;71:323-33 pubmed publisher

product information

brand :

Tocris

master code :

3535

SKU :

3535/10

product name :

Sivelestat sodium salt

description :

Selective leukocyte elastase inhibitor

target :

Synthetic Elastase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

456.44

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. Inhibits NF- B activation and LTB4-induced neutrophil transmigration in vitro . Significantly attenuates ischemia-induced spinal cord injury, decreases serum cytokine levels and reduces acute inflammatory lung injury in vivo .

catalog number base :

3535

product keywords :

Selective leukocyte elastase inhibitors inhibits Human Neutrophil Proteinases Proteases ONO5046 ONO-5046 Elastase 3535,

extended description :

Selective leukocyte elastase inhibitor

chemical name text :

N-{2-[({4-[(2,2-Dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycine sodium salt

formula :

C 20 H 21 N 2 NaO 7 S

formula text :

C20H21N2NaO7S

cas num :

150374-95-1

2020 USD :

120

2021 USD :

125 USD

alt names :

ONO-5046

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage