Sivelestat sodium salt | Tocris Bioscience 3535/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Sivelestat sodium salt

catalog :

3535/10

quantity :

10 mg (also 50 mg)

price :

164 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Assylbekova A, Zhanapiya A, Grzywa R, Sienczyk M, Sch xf6 nbach C, Burster T. Camostat Does Not Inhibit the Proteolytic Activity of Neutrophil Serine Proteases. Pharmaceuticals (Basel). 2022;15: pubmed publisher
Taya M, Garcia Hernandez M, Rangel Moreno J, Minor B, Gibbons E, Hammes S. Neutrophil elastase from myeloid cells promotes TSC2-null tumor growth. Endocr Relat Cancer. 2020;27:261-274 pubmed publisher
van den Berg M, MacCarthy Morrogh L, Carter D, Morris J, Ribeiro Bravo I, Feng Y, et al. Proteolytic and Opportunistic Breaching of the Basement Membrane Zone by Immune Cells during Tumor Initiation. Cell Rep. 2019;27:2837-2846.e4 pubmed publisher
Albrengues J, Shields M, Ng D, Park C, Ambrico A, Poindexter M, et al. Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science. 2018;361: pubmed publisher
Masood A, Yi M, Belcastro R, Li J, Lopez L, Kantores C, et al. Neutrophil elastase-induced elastin degradation mediates macrophage influx and lung injury in 60% O2-exposed neonatal rats. Am J Physiol Lung Cell Mol Physiol. 2015;309:L53-62 pubmed publisher
Saadoun S, Waters P, MacDonald C, Bell B, Vincent A, Verkman A, et al. Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain. Ann Neurol. 2012;71:323-33 pubmed publisher

product information

brand :

Tocris

master code :

3535

SKU :

3535/10

product name :

Sivelestat sodium salt

unit size :

10 mg (also 50 mg)

seo description :

Selective leukocyte elastase inhibitor

target :

Synthetic Elastase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

456.44

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Sivelestat sodium salt is a selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. Inhibits NF- B activation and LTB4-induced neutrophil transmigration in vitro . Significantly attenuates ischemia-induced spinal cord injury, decreases serum cytokine levels and reduces acute inflammatory lung injury in vivo .

top caption :

Selective leukocyte elastase inhibitor

extended description :

Selective leukocyte elastase inhibitor

chemical name text :

N-{2-[({4-[(2,2-Dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycine sodium salt

formula :

C20H21N2NaO7S

formula text :

C20H21N2NaO7S

cas num :

150374-95-1

USD :

164 USD

product details :

Selective leukocyte elastase inhibitor

alt names :

ONO-5046

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage