product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
PNU 74654
catalog :
3534/5
quantity :
5 mg (also 25 mg)
price :
108 USD
more info or order :
citations: 10
Reference
Ruggiero C, Tamburello M, Rossini E, Zini S, Durand N, Cantini G, et al. FSCN1 as a new druggable target in adrenocortical carcinoma. Int J Cancer. 2023;153:210-223 pubmed publisher
Naxerova K, Di Stefano B, Makofske J, Watson E, de Kort M, Martin T, et al. Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior. Genes Dev. 2021;35:1527-1547 pubmed publisher
Trudler D, Sanz Blasco S, Eisele Y, Ghatak S, Bodhinathan K, Akhtar M, et al. α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss. J Neurosci. 2021;41:2264-2273 pubmed publisher
Chen Y, Tristan C, Mallanna S, Ormanoglu P, Titus S, Simeonov A, et al. Chemically Defined Neural Conversion of Human Pluripotent Stem Cells. Methods Mol Biol. 2019;1919:59-72 pubmed publisher
Yang J, Kaur K, Ong L, Eisenberg C, Eisenberg L. Inhibition of G9a Histone Methyltransferase Converts Bone Marrow Mesenchymal Stem Cells to Cardiac Competent Progenitors. Stem Cells Int. 2015;2015:270428 pubmed publisher
Liao J, Karnik R, Gu H, Ziller M, Clement K, Tsankov A, et al. Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells. Nat Genet. 2015;47:469-78 pubmed publisher
Tsankov A, Gu H, Akopian V, Ziller M, Donaghey J, Amit I, et al. Transcription factor binding dynamics during human ES cell differentiation. Nature. 2015;518:344-9 pubmed publisher
Corritore E, Dugnani E, Pasquale V, Misawa R, Witkowski P, Lei J, et al. β-Cell differentiation of human pancreatic duct-derived cells after in vitro expansion. Cell Reprogram. 2014;16:456-66 pubmed publisher
Keats E, Dominguez J, Grant M, Khan Z. Switch from canonical to noncanonical Wnt signaling mediates high glucose-induced adipogenesis. Stem Cells. 2014;32:1649-60 pubmed publisher
Baril M, Es Saad S, Chatel Chaix L, Fink K, Pham T, Raymond V, et al. Genome-wide RNAi screen reveals a new role of a WNT/CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses. PLoS Pathog. 2013;9:e1003416 pubmed publisher
image
image 1 :
Tocris Bioscience 3534/5 image 1
Cat.No. 3534 - PNU 74654 C19H16N2O3 CAS No. 113906-27-7
product information
brand :
Tocris
master code :
3534
SKU :
3534/5
product name :
PNU 74654
unit size :
5 mg (also 25 mg)
seo description :
-catenin binder; inhibits Wnt signaling
target :
beta-Catenin Compounds
category :
Small Molecules
purity :
99%
observed molecular weight :
320.34
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Binds to -catenin (KD = 450 nM). Inhibits the interaction between -catenin and T cell factor 4 (Tcf4) and disrupts the Wnt signaling pathway. Promotes neural differentiation of hPSCs as part of a chemical cocktail.
top caption :
-catenin binder; inhibits Wnt signaling
extended description :
-catenin binder; inhibits Wnt signaling
chemical name text :
2-Phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydrazide
formula :
C19H16N2O3
formula text :
C19H16N2O3
cas num :
113906-27-7
USD :
108 USD
product details :
-catenin binder; inhibits Wnt signaling
storage :
Store at +4░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK