endo-IWR 1 | Tocris Bioscience 3532 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

endo-IWR 1

catalog :

3532

quantity :

10 mg (also 50 mg)

price :

165 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Garcia V, Rushton D, Tom C, Allen N, Kemp P, Svendsen C, et al. Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support. Front Neurosci. 2019;13:669 pubmed publisher
Gao X, Nowak Imialek M, Chen X, Chen D, Herrmann D, Ruan D, et al. Establishment of porcine and human expanded potential stem cells. Nat Cell Biol. 2019;21:687-699 pubmed publisher
Yamoah M, Moshref M, Sharma J, Chen W, Ledford H, Lee J, et al. Highly efficient transfection of human induced pluripotent stem cells using magnetic nanoparticles. Int J Nanomedicine. 2018;13:6073-6078 pubmed publisher
Suzuki A, Minamide R, Iwata J. The role of acetyltransferases for the temporal-specific accessibility of β-catenin to the myogenic gene locus. Sci Rep. 2018;8:15057 pubmed publisher
Kishimoto Y, Ohkawara B, Sakai T, Ito M, Masuda A, Ishiguro N, et al. Wnt/?-catenin signaling suppresses expressions of Scx, Mkx, and Tnmd in tendon-derived cells. PLoS ONE. 2017;12:e0182051 pubmed publisher
Kennedy M, Chalamalasetty R, Thomas S, Garriock R, Jailwala P, Yamaguchi T. Sp5 and Sp8 recruit Î²-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription. Proc Natl Acad Sci U S A. 2016;113:3545-50 pubmed publisher
Latos P, Goncalves A, Oxley D, Mohammed H, Turro E, Hemberger M. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Nat Commun. 2015;6:7776 pubmed publisher
Suzuki A, Pelikan R, Iwata J. WNT/Î²-Catenin Signaling Regulates Multiple Steps of Myogenesis by Regulating Step-Specific Targets. Mol Cell Biol. 2015;35:1763-76 pubmed publisher
Lindström N, Lawrence M, Burn S, Johansson J, Bakker E, Ridgway R, et al. Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron. elife. 2015;3:e04000 pubmed publisher
Cajal M, Creuzet S, Papanayotou C, SabÃ©ran Djoneidi D, Chuva de Sousa Lopes S, Zwijsen A, et al. A conserved role for non-neural ectoderm cells in early neural development. Development. 2014;141:4127-38 pubmed publisher
Iwata J, Suzuki A, Yokota T, Ho T, Pelikan R, Urata M, et al. TGFβ regulates epithelial-mesenchymal interactions through WNT signaling activity to control muscle development in the soft palate. Development. 2014;141:909-17 pubmed publisher

product information

brand :

Tocris

master code :

3532

SKU :

3532/10

product name :

endo-IWR 1

description :

Wnt/ -catenin signaling inhibitor; axin stabilizer

target :

beta-Catenin Compounds

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

409.44

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibitor of Wnt signaling. Induces an increase in axin2 protein levels; promotes -catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. Promotes endothelial cell specification of cardiac progenitor cells . Negative Control also available.

catalog number base :

3532

product keywords :

endo-IWR1 wnt signaling signalling inhibitors inhibits axin axin2 stabilizer stabiliser IWR1 beta-catenin -catenin b-catenin cardiac differentiation Beta-catenin Stem Cell Signaling Organoids 3532,

extended description :

Wnt/ -catenin signaling inhibitor; axin stabilizer

chemical name text :

[(3aR*,4S*,7R*,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide

formula :

C 25 H 19 N 3 O 3

formula text :

C25H19N3O3

cas num :

1127442-82-3

2020 USD :

157

2021 USD :

165 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage