product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
endo-IWR 1
catalog :
3532/10
quantity :
10 mg (also 50 mg)
price :
215 USD
more info or order :
citations: 29
Reference
Shono M, Kishimoto K, Hikabe O, Hayashi M, Semi K, Takashima Y, et al. Induction of primordial germ cell-like cells from common marmoset embryonic stem cells by inhibition of WNT and retinoic acid signaling. Sci Rep. 2023;13:3186 pubmed publisher
Huang H, Fang Y, Jiang M, Zhang Y, Biermann J, Melms J, et al. Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cells. elife. 2022;11: pubmed publisher
Yao X, Lu Z, Feng Z, Gao L, Zhou X, Li M, et al. Comparison of chromatin accessibility landscapes during early development of prefrontal cortex between rhesus macaque and human. Nat Commun. 2022;13:3883 pubmed publisher
Ateaque S, Merkouris S, Wyatt S, Allen N, Xie J, DiStefano P, et al. Selective activation and down-regulation of Trk receptors by neurotrophins in human neurons co-expressing TrkB and TrkC. J Neurochem. 2022;161:463-477 pubmed publisher
Thiery A, Standing A, Cooper R, Fraser G. An epithelial signalling centre in sharks supports homology of tooth morphogenesis in vertebrates. elife. 2022;11: pubmed publisher
Liu Y, Chen Q, Jeong H, Koh B, Watson E, Xu C, et al. A specialized bone marrow microenvironment for fetal haematopoiesis. Nat Commun. 2022;13:1327 pubmed publisher
Capeling M, Huang S, Childs C, Wu J, Tsai Y, Wu A, et al. Suspension culture promotes serosal mesothelial development in human intestinal organoids. Cell Rep. 2022;38:110379 pubmed publisher
Borza C, Bolás G, Bock F, Zhang X, Akabogu F, Zhang M, et al. DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3. JCI Insight. 2022;7: pubmed publisher
Koc A, Cagavi E. Replating Protocol for Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Methods Mol Biol. 2022;2520:161-170 pubmed publisher
Lee E, Seo E, Kim J, Nam S, Lee J, Jun J, et al. TAZ/Wnt-β-catenin/c-MYC axis regulates cystogenesis in polycystic kidney disease. Proc Natl Acad Sci U S A. 2020;117:29001-29012 pubmed publisher
Schick R, Farah N, Markus A, Korngreen A, Mandel Y. Electrophysiologic Characterization of Developing Human Embryonic Stem Cell-Derived Photoreceptor Precursors. Invest Ophthalmol Vis Sci. 2020;61:44 pubmed publisher
Koirala S, Klein J, Zheng Y, Glenn N, Eisemann T, Fon Tacer K, et al. Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase. Cell Rep. 2020;32:107922 pubmed publisher
Shi Y, Sun L, Wang M, Liu J, Zhong S, Li R, et al. Vascularized human cortical organoids (vOrganoids) model cortical development in vivo. PLoS Biol. 2020;18:e3000705 pubmed publisher
Garcia V, Rushton D, Tom C, Allen N, Kemp P, Svendsen C, et al. Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support. Front Neurosci. 2019;13:669 pubmed publisher
Henn I, Atkins A, Markus A, Shpun G, Barad H, Farah N, et al. SEM/FIB Imaging for Studying Neural Interfaces. Dev Neurobiol. 2020;80:305-315 pubmed publisher
Sun T, Huang Z, Zhang H, Posner C, Jia G, Ramalingam T, et al. TAZ is required for lung alveolar epithelial cell differentiation after injury. JCI Insight. 2019;5: pubmed publisher
Gao X, Nowak Imialek M, Chen X, Chen D, Herrmann D, Ruan D, et al. Establishment of porcine and human expanded potential stem cells. Nat Cell Biol. 2019;21:687-699 pubmed publisher
Yamoah M, Moshref M, Sharma J, Chen W, Ledford H, Lee J, et al. Highly efficient transfection of human induced pluripotent stem cells using magnetic nanoparticles. Int J Nanomedicine. 2018;13:6073-6078 pubmed publisher
Suzuki A, Minamide R, Iwata J. The role of acetyltransferases for the temporal-specific accessibility of β-catenin to the myogenic gene locus. Sci Rep. 2018;8:15057 pubmed publisher
Ozair M, Kirst C, van den Berg B, Ruzo A, Rito T, Brivanlou A. hPSC Modeling Reveals that Fate Selection of Cortical Deep Projection Neurons Occurs in the Subplate. Cell Stem Cell. 2018;23:60-73.e6 pubmed publisher
Kishimoto Y, Ohkawara B, Sakai T, Ito M, Masuda A, Ishiguro N, et al. Wnt/?-catenin signaling suppresses expressions of Scx, Mkx, and Tnmd in tendon-derived cells. PLoS ONE. 2017;12:e0182051 pubmed publisher
Kennedy M, Chalamalasetty R, Thomas S, Garriock R, Jailwala P, Yamaguchi T. Sp5 and Sp8 recruit β-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription. Proc Natl Acad Sci U S A. 2016;113:3545-50 pubmed publisher
Latos P, Goncalves A, Oxley D, Mohammed H, Turro E, Hemberger M. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Nat Commun. 2015;6:7776 pubmed publisher
Tesfay L, Clausen K, Kim J, Hegde P, Wang X, Miller L, et al. Hepcidin regulation in prostate and its disruption in prostate cancer. Cancer Res. 2015;75:2254-63 pubmed publisher
Suzuki A, Pelikan R, Iwata J. WNT/β-Catenin Signaling Regulates Multiple Steps of Myogenesis by Regulating Step-Specific Targets. Mol Cell Biol. 2015;35:1763-76 pubmed publisher
Lindström N, Lawrence M, Burn S, Johansson J, Bakker E, Ridgway R, et al. Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron. elife. 2015;3:e04000 pubmed publisher
Gao W, Zhou P, Ma X, Tschudy Seney B, Chen J, Magner N, et al. Ethanol negatively regulates hepatic differentiation of hESC by inhibition of the MAPK/ERK signaling pathway in vitro. PLoS ONE. 2014;9:e112698 pubmed publisher
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Iwata J, Suzuki A, Yokota T, Ho T, Pelikan R, Urata M, et al. TGFβ regulates epithelial-mesenchymal interactions through WNT signaling activity to control muscle development in the soft palate. Development. 2014;141:909-17 pubmed publisher
product information
brand :
Tocris
master code :
3532
SKU :
3532/10
product name :
endo-IWR 1
unit size :
10 mg (also 50 mg)
seo description :
Wnt/ -catenin signaling inhibitor; axin stabilizer
target :
beta-Catenin Compounds
category :
Small Molecules
purity :
98%
observed molecular weight :
409.44
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
endo -IWR 1 is an inhibitor of Wnt signaling. Induces an increase in axin2 protein levels; promotes -catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. Promotes endothelial cell specification of cardiac progenitor cells and may be used in protocols for the generation of retinal pigment epithelial cells from hPSCs. . Negative Control also available. . endo-IWR 1 synthesized to Ancillary Material Grade also available. . For more information about how endo-IWR 1 may be used, see our protocol: Generation and Propagation of EPS cells (LCDM Cocktail) .
top caption :
Wnt/ -catenin signaling inhibitor; axin stabilizer
extended description :
Wnt/ -catenin signaling inhibitor; axin stabilizer
chemical name text :
rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide
formula :
C25H19N3O3
formula text :
C25H19N3O3
cas num :
1127442-82-3
USD :
215 USD
product details :
Wnt/ -catenin signaling inhibitor; axin stabilizer
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK