SCIO 469 hydrochloride | Tocris Bioscience 3528 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SCIO 469 hydrochloride

catalog :

3528

quantity :

10 mg (also 50 mg)

price :

257 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Lin Y, Tseng I, Kuo C, Lin H, Chiu I, Chiu H. High-level expression of ARID1A predicts a favourable outcome in triple-negative breast cancer patients receiving paclitaxel-based chemotherapy. J Cell Mol Med. 2018;22:2458-2468 pubmed publisher
Heward J, Roux B, Lindsay M. Divergent signalling pathways regulate lipopolysaccharide-induced eRNA expression in human monocytic THP1 cells. FEBS Lett. 2015;589:396-406 pubmed publisher

product information

brand :

Tocris

master code :

3528

SKU :

3528/10

product name :

SCIO 469 hydrochloride

description :

Selective p38 MAPK inhibitor

target :

p38 Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

549.46

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective, ATP-competitive p38 inhibitor (IC50 = 9 nM for p38 in vitro ). Displays approximately 10-fold selectivity for p38 over p38 and 2000-fold selectivity for p38 over 20 other kinases. Reduces p38 phosphorylation in multiple myeloma cells in vitro and in vivo ; activity results in decreased tumor burden and angiogenesis in murine models of multiple myeloma. Also enhances bortezomib-induced cytotoxicity against multiple myeloma cells.

catalog number base :

3528

product keywords :

SCIO469 hydrochloride p38 MAPK selective inhibitors inhibits p38a p38alpha p38 multiple myeloma 309913-83-5 p38 3528,

extended description :

Selective p38 MAPK inhibitor

chemical name text :

6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-N,N,1-trimethyl- -oxo-1H-Indole-3-acetamide hydrochloride

formula :

C 27 H 30 ClFN 4 O 3 .HCl

formula text :

C27H30ClFN4O3.HCl

2020 USD :

249

2021 USD :

257 USD

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage