SCIO 469 hydrochloride | Tocris Bioscience 3528/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SCIO 469 hydrochloride

catalog :

3528/10

quantity :

10 mg (also 50 mg)

price :

319 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Oliva J, Galasinski S, Richey A, Campbell A, Meyers M, Modi N, et al. Clinically advanced p38 inhibitors suppress DUX4 expression in cellular and animal models of facioscapulohumeral muscular dystrophy. J Pharmacol Exp Ther. 2019;: pubmed publisher
Lin Y, Tseng I, Kuo C, Lin H, Chiu I, Chiu H. High-level expression of ARID1A predicts a favourable outcome in triple-negative breast cancer patients receiving paclitaxel-based chemotherapy. J Cell Mol Med. 2018;22:2458-2468 pubmed publisher
Heward J, Roux B, Lindsay M. Divergent signalling pathways regulate lipopolysaccharide-induced eRNA expression in human monocytic THP1 cells. FEBS Lett. 2015;589:396-406 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

3528

SKU :

3528/10

product name :

SCIO 469 hydrochloride

Description :

Selective p38 MAPK inhibitor

target :

p38 Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

549.46

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SCIO 469 hydrochloride is a selective, ATP-competitive p38 inhibitor (IC50 = 9 nM for p38 in vitro ). Displays approximately 10-fold selectivity for p38 over p38 and 2000-fold selectivity for p38 over 20 other kinases. Reduces p38 phosphorylation in multiple myeloma cells in vitro and in vivo ; activity results in decreased tumor burden and angiogenesis in murine models of multiple myeloma. Also enhances bortezomib -induced cytotoxicity against multiple myeloma cells.

extended description :

Selective p38 MAPK inhibitor

chemical name text :

6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-N,N,1-trimethyl- -oxo-1H-Indole-3-acetamide hydrochloride

formula :

C 27 H 30 ClFN 4 O 3 .HCl

formula text :

C27H30ClFN4O3.HCl

cas num :

2387505-88-4

USD :

319 USD

product details :

Selective p38 MAPK inhibitor

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage