Sirtinol | Tocris Bioscience 3521/10 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Sirtinol

catalog :

3521/10

quantity :

10 mg (also 50 mg)

price :

241 USD

citations: 6

Reference
Stoney P, Helfer G, Rodrigues D, Morgan P, McCaffery P. Thyroid hormone activation of retinoic acid synthesis in hypothalamic tanycytes. Glia. 2016;64:425-39 pubmed publisher
Valle C, Salvatori I, Gerbino V, Rossi S, Palamiuc L, Rene F, et al. Tissue-specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways. Cell Death Dis. 2014;5:e1296 pubmed publisher
Brose R, Shin G, McGuinness M, Schneidereith T, Purvis S, Dong G, et al. Activation of the stress proteome as a mechanism for small molecule therapeutics. Hum Mol Genet. 2012;21:4237-52 pubmed publisher
Balaiya S, Khetpal V, Chalam K. Hypoxia initiates sirtuin1-mediated vascular endothelial growth factor activation in choroidal endothelial cells through hypoxia inducible factor-2?. Mol Vis. 2012;18:114-20 pubmed
Paffett M, Lucas S, Campen M. Resveratrol reverses monocrotaline-induced pulmonary vascular and cardiac dysfunction: a potential role for atrogin-1 in smooth muscle. Vascul Pharmacol. 2012;56:64-73 pubmed publisher
Velásquez D, Martinez G, Romero A, Vazquez M, Boit K, Dopeso Reyes I, et al. The central Sirtuin 1/p53 pathway is essential for the orexigenic action of ghrelin. Diabetes. 2011;60:1177-85 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3521

SKU :

3521/10

product name :

Sirtinol

description :

Selective sirtuin family deacetylase inhibitor

target :

Class III Histone Deacetylases Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

394.47

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Sirtinol is a cell-permeable, selective sirtuin deacetylase inhibitor (IC50 values are 38, 68 and 131 M at SIRT2, Sir2p and SIRT1 respectively) that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro .

product keywords :

Selective sirtuin family deacetylases inhibitors inhibits Sirtuin Sir2-like Family Class III HDACs (Sirtuins) 3521,

extended description :

Selective sirtuin family deacetylase inhibitor

chemical name text :

2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide

formula :

C26H22N2O2

formula text :

C26H22N2O2

cas num :

410536-97-9

USD :

238

USD 2025 :

241 USD

product details :

Selective sirtuin family deacetylase inhibitor