Tunicamycin | Tocris Bioscience 3516 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Tunicamycin

catalog :

3516

quantity :

10 mg

price :

182 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Shemorry A, Harnoss J, Guttman O, Marsters S, Komuves L, Lawrence D, et al. Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress. elife. 2019;8: pubmed publisher
Zhang S, Liu D, Wang L, Li Y, Wang Y, Zhang H, et al. A CASPR1-ATP1B3 protein interaction modulates plasma membrane localization of Na+/K+-ATPase in brain microvascular endothelial cells. J Biol Chem. 2019;294:6375-6386 pubmed publisher
Skrenkova K, Lee S, Lichnerova K, Kaniaková M, Hansikova H, Zapotocky M, et al. N-Glycosylation Regulates the Trafficking and Surface Mobility of GluN3A-Containing NMDA Receptors. Front Mol Neurosci. 2018;11:188 pubmed publisher
Greer Y, Porat Shliom N, Nagashima K, Stuelten C, Crooks D, Koparde V, et al. ONC201 kills breast cancer cells in vitro by targeting mitochondria. Oncotarget. 2018;9:18454-18479 pubmed publisher
Hossain M, Barua D, Arabkari V, Islam N, Gupta A, Gupta S. Hyperactivation of nuclear receptor coactivators induces PERK-dependent cell death. Oncotarget. 2018;9:11707-11721 pubmed publisher
Bajikar S, Wang C, Borten M, Pereira E, Atkins K, Janes K. Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer. Dev Cell. 2017;43:418-435.e13 pubmed publisher
Gupta A, Hossain M, Miller N, Kerin M, Callagy G, Gupta S. NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK-eIF2Î±-ATF4 signalling in breast cancer. Oncogene. 2016;35:5860-5871 pubmed publisher
Deldicque L, Bertrand L, Patton A, Francaux M, Baar K. ER stress induces anabolic resistance in muscle cells through PKB-induced blockade of mTORC1. PLoS ONE. 2011;6:e20993 pubmed publisher

product information

brand :

Tocris

master code :

3516

SKU :

3516/10

product name :

Tunicamycin

description :

Antibiotic; GlcNAc phosphotransferase inhibitor

target :

Other Transferase Inhibitors

category :

Small Molecules

unit size :

10 mg

observed molecular weight :

844.95

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Antibiotic; inhibits GlcNAc phosphotransferase (GPT). Blocks the formation of N-glycosidic linkages by inhibiting the first step in glycoprotein synthesis. Activity induces ER stress and causes G1 arrest; can be used to induce autophagy. Tunicamycin contains four main components as follows: Homolog A, n=8, C37H60N4O16, molecular weight = 816.90 Homolog B, n=9, C38H62N4O16, molecular weight = 830.93 Homolog C, n=10, C39H64N4O16, molecular weight = 844.95 Homolog D, n=11, C40H66N4O16, molecular weight = 858.99 The composition of this product will vary from batch to batch and can be found on the relevant certificate of analysis.

catalog number base :

3516

product keywords :

antibiotics GlcNAc phosphotransferases GTP protein glycosylation inhibitors inhibits Other Transferases Antibiotics Autophagy 3516,

extended description :

Antibiotic; GlcNAc phosphotransferase inhibitor

chemical name text :

Tunicamycin from Streptomyces sp.

formula :

C 39 H 64 N 4 O 16 (tunicamycin C, n=10)

formula text :

C39H64N4O16 (tunicamycin C, n=10)

cas num :

11089-65-9

2020 USD :

178

2021 USD :

182 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage