product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Tunicamycin
catalog :
3516/10
quantity :
10 mg
price :
227 USD
more info or order :
citations: 26
Reference
Sosa Carrillo S, Galez H, Napolitano S, Bertaux F, Batt G. Maximizing protein production by keeping cells at optimal secretory stress levels using real-time control approaches. Nat Commun. 2023;14:3028 pubmed publisher
Woodley K, Dillingh L, Giotopoulos G, Madrigal P, Rattigan K, Philippe C, et al. Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death. Nat Commun. 2023;14:2132 pubmed publisher
Charrin E, Dabaghie D, Sen I, Unnersj xf6 Jess D, M xf6 ller Hackbarth K, Burmakin M, et al. Soluble Klotho protects against glomerular injury through regulation of ER stress response. Commun Biol. 2023;6:208 pubmed publisher
Thepsuwan P, Bhattacharya A, Song Z, Hippleheuser S, Feng S, Wei X, et al. Hepatic SEL1L-HRD1 ER-associated degradation regulates systemic iron homeostasis via ceruloplasmin. Proc Natl Acad Sci U S A. 2023;120:e2212644120 pubmed publisher
Paul S, Dansithong W, Gandelman M, Figueroa K, Zu T, Ranum L, et al. Staufen Impairs Autophagy in Neurodegeneration. Ann Neurol. 2022;: pubmed publisher
Shang L, Aughey E, Kim H, Heden T, Wang L, Najt C, et al. Systemic lipolysis promotes physiological fitness in Drosophila melanogaster. Aging (Albany NY). 2022;14:6481-6506 pubmed publisher
Domenger A, Choisy C, Baron L, Mayau V, Perthame E, Deriano L, et al. The Sec61 translocon is a therapeutic vulnerability in multiple myeloma. EMBO Mol Med. 2022;14:e14740 pubmed publisher
Place D, Samir P, Malireddi R, Kanneganti T. Integrated stress response restricts macrophage necroptosis. Life Sci Alliance. 2022;5: pubmed publisher
Zundell J, Fukumoto T, Lin J, Fatkhudinov N, Nacarelli T, Kossenkov A, et al. Targeting the IRE1α/XBP1 Endoplasmic Reticulum Stress Response Pathway in ARID1A-Mutant Ovarian Cancers. Cancer Res. 2021;81:5325-5335 pubmed publisher
Weng J, Koch P, Luan H, Tu H, Shimada K, Ngan I, et al. Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation. Nat Metab. 2021;3:513-522 pubmed publisher
Barghout S, Aman A, Nouri K, Blatman Z, Arevalo K, Thomas G, et al. A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity. JCI Insight. 2021;: pubmed publisher
Ucuncu E, Rajamani K, Wilson M, Medina Cano D, Altin N, David P, et al. MINPP1 prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia. Nat Commun. 2020;11:6087 pubmed publisher
Afrin T, Seok M, Terry B, Pajerowska Mukhtar K. Probing natural variation of IRE1 expression and endoplasmic reticulum stress responses in Arabidopsis accessions. Sci Rep. 2020;10:19154 pubmed publisher
Zhu B, Daoud F, Zeng S, Matic L, Hedin U, Uvelius B, et al. Antagonistic relationship between the unfolded protein response and myocardin-driven transcription in smooth muscle. J Cell Physiol. 2020;: pubmed publisher
Li C, Grider J, Murthy K, Bohl J, Rivet E, Wieghard N, et al. Endoplasmic Reticulum Stress in Subepithelial Myofibroblasts Increases the TGF-β1 Activity That Regulates Fibrosis in Crohn's Disease. Inflamm Bowel Dis. 2020;26:809-819 pubmed publisher
Shemorry A, Harnoss J, Guttman O, Marsters S, Komuves L, Lawrence D, et al. Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress. elife. 2019;8: pubmed publisher
Zhang S, Liu D, Wang L, Li Y, Wang Y, Zhang H, et al. A CASPR1-ATP1B3 protein interaction modulates plasma membrane localization of Na+/K+-ATPase in brain microvascular endothelial cells. J Biol Chem. 2019;294:6375-6386 pubmed publisher
Medina Cano D, Ucuncu E, Nguyen L, Nicouleau M, Lipecka J, Bizot J, et al. High N-glycan multiplicity is critical for neuronal adhesion and sensitizes the developing cerebellum to N-glycosylation defect. elife. 2018;7: pubmed publisher
Chang T, Lawrence D, Lu M, Tan J, Harnoss J, Marsters S, et al. Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate. Mol Cell. 2018;71:629-636.e5 pubmed publisher
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product information
brand :
Tocris, a Bio-Techne Brand
catalog number base :
3516
SKU :
3516/10
product name :
Tunicamycin
Description :
Antibiotic; GlcNAc phosphotransferase inhibitor
target :
Other Transferase Inhibitors
category :
Small Molecules
unit size :
10 mg
purity :
98%
observed molecular weight :
844.95
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Tunicamycin is an antibiotic; inhibits GlcNAc phosphotransferase (GPT). Blocks the formation of N-glycosidic linkages by inhibiting the first step in glycoprotein synthesis. Activity induces ER stress and causes G1 arrest; can be used to induce autophagy. Tunicamycin contains four main components as follows: Homolog A, n=8, C37H60N4O16, molecular weight = 816.90 Homolog B, n=9, C38H62N4O16, molecular weight = 830.93 Homolog C, n=10, C39H64N4O16, molecular weight = 844.95 Homolog D, n=11, C40H66N4O16, molecular weight = 858.99 The composition of this product will vary from batch to batch and can be found on the relevant certificate of analysis.
extended description :
Antibiotic; GlcNAc phosphotransferase inhibitor
chemical name text :
Tunicamycin from Streptomyces sp.
formula :
C 39 H 64 N 4 O 16 (tunicamycin C, n=10)
formula text :
C39H64N4O16 (tunicamycin C, n=10)
cas num :
11089-65-9
USD :
227 USD
product details :
Antibiotic; GlcNAc phosphotransferase inhibitor
storage :
Store at +4°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK