FK 228 | Tocris Bioscience 3515/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

FK 228

catalog :

3515/1

quantity :

1 mg

price :

358 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Calabrese B, Jones S, Shiraishi Yamaguchi Y, Lingelbach M, Manor U, Svitkina T, et al. INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury. Nat Commun. 2022;13:6037 pubmed publisher
Zemskov E, Gross C, Aggarwal S, Zemskova M, Wu X, Gu C, et al. NF-κB-dependent repression of Sox18 transcription factor requires the epigenetic regulators histone deacetylases 1 and 2 in acute lung injury. Front Physiol. 2022;13:947537 pubmed publisher
Pozo K, Zahler S, Ishimatsu K, Carter A, Telange R, Tan C, et al. Preclinical characterization of tyrosine kinase inhibitor-based targeted therapies for neuroendocrine thyroid cancer. Oncotarget. 2018;9:37662-37675 pubmed publisher
Fukuda T, Wu W, Okada M, Maeda I, Kojima Y, Hayami R, et al. Class I histone deacetylase inhibitors inhibit the retention of BRCA1 and 53BP1 at the site of DNA damage. Cancer Sci. 2015;106:1050-6 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

3515

SKU :

3515/1

product name :

FK 228

Description :

Potent and selective class I histone deacetylase inhibitor; antitumor

target :

Class I Histone Deacetylases Inhibitors

category :

Small Molecules

unit size :

1 mg

purity :

98%

observed molecular weight :

540.7

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

FK 228 is a potent and selective inhibitor of class I histone deacetylases (HDACs) (IC50 values are 36, 47, 510 and 14,000 nM for HDAC1, HDAC2, HDAC4 and HDAC6 respectively). Exhibits cytotoxicity against various human tumor cell lines; also exhibits antitumor activity against human tumor xenografts.

extended description :

Potent and selective class I histone deacetylase inhibitor; antitumor

chemical name text :

Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3-5) disulfide

formula :

C 24 H 36 N 4 O 6 S 2

formula text :

C24H36N4O6S2

cas num :

128517-07-7

USD :

358 USD

product details :

Potent and selective class I histone deacetylase inhibitor; antitumor

alt names :

Depsipeptide, FR 901228, Romidepsin

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage