product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
BMS 493
catalog :
3509
quantity :
10 mg (also 50 mg)
price :
220 USD
more info or order :
citations: 15
Reference
Comai G, Tesarova M, Dupé V, Rhinn M, Vallecillo García P, da Silva F, et al. Local retinoic acid signaling directs emergence of the extraocular muscle functional unit. PLoS Biol. 2020;18:e3000902 pubmed publisher
Cordeiro T, Sibille N, Germain P, Barthe P, Boulahtouf A, Allemand F, et al. Interplay of Protein Disorder in Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression. Structure. 2019;: pubmed publisher
Ng Blichfeldt J, Schrik A, Kortekaas R, Noordhoek J, Heijink I, Hiemstra P, et al. Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation. EBioMedicine. 2018;36:461-474 pubmed publisher
Metzler M, Raja S, Elliott K, Friedl R, Tran N, Brugmann S, et al. RDH10-mediated retinol metabolism and RARα-mediated retinoic acid signaling are required for submandibular salivary gland initiation. Development. 2018;145: pubmed publisher
Bohnenpoll T, Weiss A, Labuhn M, Lüdtke T, Trowe M, Kispert A. Retinoic acid signaling maintains epithelial and mesenchymal progenitors in the developing mouse ureter. Sci Rep. 2017;7:14803 pubmed publisher
Wang B, Fu X, Liang X, Deavila J, Wang Z, Zhao L, et al. Retinoic acid induces white adipose tissue browning by increasing adipose vascularity and inducing beige adipogenesis of PDGFRα+ adipose progenitors. Cell Discov. 2017;3:17036 pubmed publisher
Wang B, Fu X, Liang X, Wang Z, Yang Q, Zou T, et al. Maternal Retinoids Increase PDGFR?+ Progenitor Population and Beige Adipogenesis in Progeny by Stimulating Vascular Development. EBioMedicine. 2017;18:288-299 pubmed publisher
Pei F, Jiang J, Bai S, Cao H, Tian L, Zhao Y, et al. Chemical-defined and albumin-free generation of human atrial and ventricular myocytes from human pluripotent stem cells. Stem Cell Res. 2017;19:94-103 pubmed publisher
Abashev T, Metzler M, Wright D, Sandell L. Retinoic acid signaling regulates Krt5 and Krt14 independently of stem cell markers in submandibular salivary gland epithelium. Dev Dyn. 2017;246:135-147 pubmed publisher
Bhattacharya N, Yuan R, Prestwood T, Penny H, DiMaio M, Reticker Flynn N, et al. Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8(+) T Cell-Mediated Immunity in Colorectal Cancer. Immunity. 2016;45:641-655 pubmed publisher
Thiede B, Mann Z, Chang W, Ku Y, Son Y, Lovett M, et al. Retinoic acid signalling regulates the development of tonotopically patterned hair cells in the chicken cochlea. Nat Commun. 2014;5:3840 pubmed publisher
van de Pavert S, Ferreira M, Domingues R, Ribeiro H, Molenaar R, Moreira Santos L, et al. Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity. Nature. 2014;508:123-7 pubmed publisher
Johansson H, Sanchez B, Mundt F, Forshed J, Kovács A, Panizza E, et al. Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer. Nat Commun. 2013;4:2175 pubmed publisher
Raverdeau M, Gely Pernot A, Féret B, Dennefeld C, Benoit G, Davidson I, et al. Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis. Proc Natl Acad Sci U S A. 2012;109:16582-7 pubmed publisher
Rankin S, Gallas A, Neto A, Gomez Skarmeta J, Zorn A. Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus. Development. 2012;139:3010-20 pubmed publisher
product information
brand :
Tocris
master code :
3509
SKU :
3509/10
product name :
BMS 493
description :
Pan-RAR inverse agonist
target :
Retinoic Acid Receptor Inverse Agonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
404.5
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Pan-retinoic acid receptor (pan-RAR) inverse agonist. Enhances nuclear corepressor (NCoR) interaction with RARs. Binding induces analogous conformational changes in all RAR types (RAR , RAR and RAR ).
catalog number base :
3509
product keywords :
BMS493 retinoic acid receptors agonists RAR agonists inverse pan-RAR Retinoic Acid Receptors 3509,
extended description :
Pan-RAR inverse agonist
chemical name text :
4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoic acid
formula :
C 29 H 24 O 2
formula text :
C29H24O2
cas num :
215030-90-3
2020 USD :
209
2021 USD :
220 USD
storage :
Store at +4°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK