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company name :
Tocris Bioscience
product type :
chemical
product name :
BMS 493
catalog :
3509/10
quantity :
10 mg (also 50 mg)
price :
279 USD
more info or order :
citations: 29
Reference
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Telias M, Sit K, Frozenfar D, Smith B, Misra A, Goard M, et al. Retinoic acid inhibitors mitigate vision loss in a mouse model of retinal degeneration. Sci Adv. 2022;8:eabm4643 pubmed publisher
da Silva F, Jian Motamedi F, Weerasinghe Arachchige L, Tison A, Bradford S, Lefebvre J, et al. Retinoic acid signaling is directly activated in cardiomyocytes and protects mouse hearts from apoptosis after myocardial infarction. elife. 2021;10: pubmed publisher
Kinoshita M, Barber M, Mansfield W, Cui Y, Spindlow D, Stirparo G, et al. Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency. Cell Stem Cell. 2021;28:453-471.e8 pubmed publisher
Comai G, Tesarova M, Dupé V, Rhinn M, Vallecillo García P, da Silva F, et al. Local retinoic acid signaling directs emergence of the extraocular muscle functional unit. PLoS Biol. 2020;18:e3000902 pubmed publisher
Zhao L, Son J, Wang B, Tian Q, Chen Y, Liu X, et al. Retinoic acid signalling in fibro/adipogenic progenitors robustly enhances muscle regeneration. EBioMedicine. 2020;60:103020 pubmed publisher
Wang J, Li G, Hu L, Yan F, Zhao B, Wu X, et al. Retinoic Acid Signal Negatively Regulates Osteo/Odontogenic Differentiation of Dental Pulp Stem Cells. Stem Cells Int. 2020;2020:5891783 pubmed publisher
Devalaraja S, To T, Folkert I, Natesan R, Alam M, Li M, et al. Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression. Cell. 2020;180:1098-1114.e16 pubmed publisher
Buechler M, Kim K, Onufer E, Williams J, Little C, Dominguez C, et al. A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages. Immunity. 2019;: pubmed publisher
Cordeiro T, Sibille N, Germain P, Barthe P, Boulahtouf A, Allemand F, et al. Interplay of Protein Disorder in Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression. Structure. 2019;: pubmed publisher
Harris T, Gattu S, Propheter D, Kuang Z, Bel S, Ruhn K, et al. Resistin-like Molecule α Provides Vitamin-A-Dependent Antimicrobial Protection in the Skin. Cell Host Microbe. 2019;25:777-788.e8 pubmed publisher
Weiss A, Bohnenpoll T, Kurz J, Blank P, Airik R, L xfc dtke T, et al. Delayed onset of smooth muscle cell differentiation leads to hydroureter formation in mice with conditional loss of the zinc finger transcription factor gene Gata2 in the ureteric mesenchyme. J Pathol. 2019;248:452-463 pubmed publisher
Al Nabhani Z, Dulauroy S, Marques R, Cousu C, Al Bounny S, Déjardin F, et al. A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult. Immunity. 2019;50:1276-1288.e5 pubmed publisher
Ng Blichfeldt J, Schrik A, Kortekaas R, Noordhoek J, Heijink I, Hiemstra P, et al. Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation. EBioMedicine. 2018;36:461-474 pubmed publisher
Metzler M, Raja S, Elliott K, Friedl R, Tran N, Brugmann S, et al. RDH10-mediated retinol metabolism and RARα-mediated retinoic acid signaling are required for submandibular salivary gland initiation. Development. 2018;145: pubmed publisher
Taguchi A, Nishinakamura R. Higher-Order Kidney Organogenesis from Pluripotent Stem Cells. Cell Stem Cell. 2017;21:730-746.e6 pubmed publisher
Bohnenpoll T, Weiss A, Labuhn M, Lüdtke T, Trowe M, Kispert A. Retinoic acid signaling maintains epithelial and mesenchymal progenitors in the developing mouse ureter. Sci Rep. 2017;7:14803 pubmed publisher
Wang B, Fu X, Liang X, Deavila J, Wang Z, Zhao L, et al. Retinoic acid induces white adipose tissue browning by increasing adipose vascularity and inducing beige adipogenesis of PDGFRα+ adipose progenitors. Cell Discov. 2017;3:17036 pubmed publisher
Gouti M, Delile J, Stamataki D, Wymeersch F, Huang Y, Kleinjung J, et al. A Gene Regulatory Network Balances Neural and Mesoderm Specification during Vertebrate Trunk Development. Dev Cell. 2017;41:243-261.e7 pubmed publisher
Wang B, Fu X, Liang X, Wang Z, Yang Q, Zou T, et al. Maternal Retinoids Increase PDGFR?+ Progenitor Population and Beige Adipogenesis in Progeny by Stimulating Vascular Development. EBioMedicine. 2017;18:288-299 pubmed publisher
Pei F, Jiang J, Bai S, Cao H, Tian L, Zhao Y, et al. Chemical-defined and albumin-free generation of human atrial and ventricular myocytes from human pluripotent stem cells. Stem Cell Res. 2017;19:94-103 pubmed publisher
Abashev T, Metzler M, Wright D, Sandell L. Retinoic acid signaling regulates Krt5 and Krt14 independently of stem cell markers in submandibular salivary gland epithelium. Dev Dyn. 2017;246:135-147 pubmed publisher
Bhattacharya N, Yuan R, Prestwood T, Penny H, DiMaio M, Reticker Flynn N, et al. Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8(+) T Cell-Mediated Immunity in Colorectal Cancer. Immunity. 2016;45:641-655 pubmed publisher
Wright D, Buenger D, Abashev T, Lindeman R, Ding J, Sandell L. Retinoic acid regulates embryonic development of mammalian submandibular salivary glands. Dev Biol. 2015;407:57-67 pubmed publisher
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product information
brand :
Tocris, a Bio-Techne Brand
catalog number base :
3509
SKU :
3509/10
product name :
BMS 493
Description :
Pan-RAR inverse agonist
target :
Retinoic Acid Receptor Inverse Agonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
404.5
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
BMS 493 is a pan-retinoic acid receptor (pan-RAR) inverse agonist. Enhances nuclear corepressor (NCoR) interaction with RARs. Binding induces analogous conformational changes in all RAR types (RAR , RAR and RAR ).
extended description :
Pan-RAR inverse agonist
chemical name text :
4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoic acid
formula :
C 29 H 24 O 2
formula text :
C29H24O2
cas num :
215030-90-3
USD :
279 USD
product details :
Pan-RAR inverse agonist
storage :
Store at +4°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK