AM 80 | Tocris Bioscience 3507/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AM 80

catalog :

3507/10

quantity :

10 mg (also 50 mg)

price :

263 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Johnson J, De Veaux N, Rives A, Lahaye X, Lucas S, Perot B, et al. A Comprehensive Map of the Monocyte-Derived Dendritic Cell Transcriptional Network Engaged upon Innate Sensing of HIV. Cell Rep. 2020;30:914-931.e9 pubmed publisher
Duprey Díaz M, Blagburn J, Blanco R. Exogenous Modulation of Retinoic Acid Signaling Affects Adult RGC Survival in the Frog Visual System after Optic Nerve Injury. PLoS ONE. 2016;11:e0162626 pubmed publisher
Gupta K, Gulen F, Sun L, Aguilera R, Chakrabarti A, Kiselar J, et al. GSK3 is a regulator of RAR-mediated differentiation. Leukemia. 2012;26:1277-85 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3507

SKU :

3507/10

product name :

AM 80

description :

RAR agonist; anticancer agent

target :

Retinoic Acid Receptor Agonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at RT

observed molecular weight :

351.44

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AM 80 is a retinoic acid receptor (RAR ) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro . Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 M respectively) and displays anticancer activity against acute promyelocytic leukemia in vivo . AM 80 is a cell cycle activator in hiPSC-derived cardiomyocytes, and pretreatment with AM 80 promotes engraftment of cardiomyocytes in mice with heart damage.

product keywords :

RAR RARalpha agonists anticancer Retinoic Acid Receptors AM80 cardiomyocytes cell cycle activators activation Tamibarotene Retinoic Acid Receptors Cardiomyocyte Stem Cells 3507,

extended description :

RAR agonist; anticancer agent

chemical name text :

4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]benzoic acid

formula :

C22H25NO3

formula text :

C22H25NO3

cas num :

94497-51-5

USD :

255

USD 2025 :

263 USD

product details :

RAR agonist; anticancer agent

alt names :

Tamibarotene

more info or order :

Tocris Bioscience product webpage