HLI 373 | Tocris Bioscience 3503/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

HLI 373

catalog :

3503/10

quantity :

10 mg (also 50 mg)

price :

217 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

3503

SKU :

3503/10

product name :

HLI 373

Description :

Hdm2 inhibitor; activates p53-dependent transcription

target :

p53 Activators

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

414.33

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3). Blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53; activates p53-dependent transcription. Induces apoptosis in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS.

extended description :

Hdm2 inhibitor; activates p53-dependent transcription

chemical name text :

5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione dihydrochloride

formula :

C 18 H 23 N 5 O 2 .2HCl

formula text :

C18H23N5O2.2HCl

cas num :

1782531-99-0

USD :

217 USD

product details :

Hdm2 inhibitor; activates p53-dependent transcription

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage