Epothilone B | Tocris Bioscience 3502/100 product information

product summary

request information :

company name :

Tocris Bioscience

product type :

chemical

product name :

Epothilone B

catalog :

3502/100

quantity :

100µg

price :

295 USD

more info or order :

Tocris Bioscience product webpage

product information

CHEMISTRY :

CC1=NC(/C=[C@](C)/[C@@H](OC2=O)C[C@H]3[C@@](O3)(C)CCC[C@H](C)[C@H](O)[C@H](C([C@@](C)(C)[C@@H](O)C2)=O)C)=CS1

Cat Number :

3502/100

Product Name :

Epothilone B

Cas Number :

[152044-54-7]

Unit Size :

100µg

Size :

100

Unit :

µg

USD :

295 USD

Primary Category :

Cell Biology

Secondary Category :

Cytoskeleton and Motor Proteins

Tertiary Category :

Microtubules

Primary Action :

Microtubule stabilization agent; promotes tubulin polymerization

Biological Description :

Microtubule stabilization agent that promotes tubulin polymerization and induces G2-M cell cycle arrest (EC50 = 32 nM in HeLa cells). Inhibits proliferation of human carcinoma cell lines in vitro, including MDR cells overexpressing the P-glycoprotein efflux pump. Exhibits potent cytotoxicity in MCF-7 and A549 cells (EC50 values are 0.3 and 2.7 nM respectively). Inhibits growth of HCT-15 tumors in mice in vivo.

Formula :

C27H41NO6S

Molwt :

507.68

Synonyms :

Patupilone

more info or order :

Tocris Bioscience product webpage