Decanoyl-RVKR-CMK | Tocris Bioscience 3501 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Decanoyl-RVKR-CMK

catalog :

3501

quantity :

1 mg

price :

185 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Cheng Y, Chao T, Li C, Chiu M, Kao H, Wang S, et al. Furin Inhibitors Block SARS-CoV-2 Spike Protein Cleavage to Suppress Virus Production and Cytopathic Effects. Cell Rep. 2020;33:108254 pubmed publisher
Hoffmann M, Kleine Weber H, Pohlmann S. A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells. Mol Cell. 2020;78:779-784.e5 pubmed publisher
Wang E, Rafatian N, Zhao Y, Lee A, Lai B, Lu R, et al. Biowire Model of Interstitial and Focal Cardiac Fibrosis. ACS Cent Sci. 2019;5:1146-1158 pubmed publisher
Matsuyama S, Shirato K, Kawase M, Terada Y, Kawachi K, Fukushi S, et al. Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells. J Virol. 2018;92: pubmed publisher
Millet J, Whittaker G. Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein. Proc Natl Acad Sci U S A. 2014;111:15214-9 pubmed publisher
Edin N. The role of interleukin-13 in the removal of hyper-radiosensitivity by priming irradiation. J Radiat Res. 2014;55:1066-74 pubmed publisher

product information

brand :

Tocris

master code :

3501

SKU :

3501/1

product name :

Decanoyl-RVKR-CMK

description :

Subtilisin/Kex2p-like proprotein convertase inhibitor

target :

Additional Synthetic Protease Inhibitors

category :

Peptides

unit size :

1 mg

observed molecular weight :

744.42

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=peptides

details of functionality :

Subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in PC12 cells. Also inhibits cleavage of SARS-CoV-2 spike protein by furin and blocks viral cell entry (IC50 = 57 nM in plaque reduction assay).

catalog number base :

3501

product keywords :

proprotein convertases inhibitors inhibits supplier proteolytic cleavage calcium dependent serine endopeptidases furin PC1 PC2 PC4 PACE4 PC5 PC7 secretory pathway MERS SARS Other Proteases Furin 3501,

extended description :

Subtilisin/Kex2p-like proprotein convertase inhibitor

formula :

C 34 H 66 ClN 11 O 5

formula text :

C34H66ClN11O5

cas num :

150113-99-8

2020 USD :

176

2021 USD :

185 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage