Decanoyl-RVKR-CMK | Tocris Bioscience 3501/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Decanoyl-RVKR-CMK

catalog :

3501/1

quantity :

1 mg

price :

235 USD

more info or order :

Tocris Bioscience product webpage

citations: 13

Reference
Sych T, Schlegel J, Barriga H, Ojansivu M, Hanke L, Weber F, et al. High-throughput measurement of the content and properties of nano-sized bioparticles with single-particle profiler. Nat Biotechnol. 2023;: pubmed publisher
Chen J, Yang X, Si H, Gong Q, Que T, Li J, et al. A bat MERS-like coronavirus circulates in pangolins and utilizes human DPP4 and host proteases for cell entry. Cell. 2023;186:850-863.e16 pubmed publisher
Chang C, Parsi K, Somasundaran M, Vanderleeden E, Liu P, Cruz J, et al. A Newly Engineered A549 Cell Line Expressing ACE2 and TMPRSS2 Is Highly Permissive to SARS-CoV-2, Including the Delta and Omicron Variants. Viruses. 2022;14: pubmed publisher
Sanders D, Jumper C, Ackerman P, Bracha D, Donlic A, Kim H, et al. SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation. elife. 2021;10: pubmed publisher
Chu H, Hu B, Huang X, Chai Y, Zhou D, Wang Y, et al. Host and viral determinants for efficient SARS-CoV-2 infection of the human lung. Nat Commun. 2021;12:134 pubmed publisher
Al Rifai O, Julien C, LaCombe J, Faubert D, Lira Navarrete E, Narimatsu Y, et al. The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans. elife. 2020;9: pubmed publisher
Cheng Y, Chao T, Li C, Chiu M, Kao H, Wang S, et al. Furin Inhibitors Block SARS-CoV-2 Spike Protein Cleavage to Suppress Virus Production and Cytopathic Effects. Cell Rep. 2020;33:108254 pubmed publisher
Hoffmann M, Kleine Weber H, Pohlmann S. A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells. Mol Cell. 2020;78:779-784.e5 pubmed publisher
Wang E, Rafatian N, Zhao Y, Lee A, Lai B, Lu R, et al. Biowire Model of Interstitial and Focal Cardiac Fibrosis. ACS Cent Sci. 2019;5:1146-1158 pubmed publisher
Matsuyama S, Shirato K, Kawase M, Terada Y, Kawachi K, Fukushi S, et al. Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells. J Virol. 2018;92: pubmed publisher
Ventura E, Weller M, Burghardt I. Cutting Edge: ERK1 Mediates the Autocrine Positive Feedback Loop of TGF-? and Furin in Glioma-Initiating Cells. J Immunol. 2017;198:4569-4574 pubmed publisher
Millet J, Whittaker G. Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein. Proc Natl Acad Sci U S A. 2014;111:15214-9 pubmed publisher
Edin N. The role of interleukin-13 in the removal of hyper-radiosensitivity by priming irradiation. J Radiat Res. 2014;55:1066-74 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

3501

SKU :

3501/1

product name :

Decanoyl-RVKR-CMK

Description :

Subtilisin/Kex2p-like proprotein convertase inhibitor

target :

Furin Inhibitors

category :

Peptides

unit size :

1 mg

purity :

95%

observed molecular weight :

744.42

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=peptides

details of functionality :

Decanoyl-RVKR-CMK is a subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in PC12 cells. Inhibits cleavage of glycoprotein B of human cytomegalovirus. Also inhibits cleavage of SARS-CoV-2 spike protein by furin and blocks viral cell entry (IC50 = 57 nM in plaque reduction assay).

extended description :

Subtilisin/Kex2p-like proprotein convertase inhibitor

formula :

C 34 H 66 ClN 11 O 5

formula text :

C34H66ClN11O5

cas num :

150113-99-8

USD :

235 USD

product details :

Subtilisin/Kex2p-like proprotein convertase inhibitor

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage