BX 471 | Tocris Bioscience 3496/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BX 471

catalog :

3496/10

quantity :

10 mg (also 50 mg)

price :

327 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

3496

SKU :

3496/10

product name :

BX 471

Description :

Potent, selective CCR1 antagonist

target :

Chemokine Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

434.89

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

BX 471 is a potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1). Exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. Inhibits MIP- /CCL3-induced intracellular Ca2+ mobilization. Orally active; effectively reduces disease severity in a rat model of multiple sclerosis. Decreases renal fibrosis in a mouse model of obstructive nephropathy.

extended description :

Potent, selective CCR1 antagonist

chemical name text :

(2R)-1-[[2-[(Aminocarbonyl)amino]-4-chlorophenoxy]acetyl]-4-[(4-fluorophenyl)methyl]-2-methylpiperazine

formula :

C 21 H 24 ClFN 4 O 3

formula text :

C21H24ClFN4O3

cas num :

217645-70-0

USD :

327 USD

product details :

Potent, selective CCR1 antagonist

alt names :

ZK-811752

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage