Fludarabine | Tocris Bioscience 3495/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Fludarabine

catalog :

3495/10

quantity :

10 mg (also 50 mg)

price :

195 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Benvie A, Lee D, Steiner B, Xue S, Jiang Y, Berry D. Age-dependent Pdgfrβ signaling drives adipocyte progenitor dysfunction to alter the beige adipogenic niche in male mice. Nat Commun. 2023;14:1806 pubmed publisher
Bergant V, Yamada S, Grass V, Tsukamoto Y, Lavacca T, Krey K, et al. Attenuation of SARS-CoV-2 replication and associated inflammation by concomitant targeting of viral and host cap 2'-O-ribose methyltransferases. EMBO J. 2022;41:e111608 pubmed publisher
Piao H, Fu L, Wang Y, Liu Y, Wang Y, Meng X, et al. A positive feedback loop between gastric cancer cells and tumor-associated macrophage induces malignancy progression. J Exp Clin Cancer Res. 2022;41:174 pubmed publisher
Nascimento Da Conceicao V, Sun Y, Ramachandran K, Chauhan A, Raveendran A, Venkatesan M, et al. Resolving macrophage polarization through distinct Ca2+ entry channel that maintains intracellular signaling and mitochondrial bioenergetics. iScience. 2021;24:103339 pubmed publisher
Kuzumi A, Yoshizaki A, Matsuda K, Kotani H, Norimatsu Y, Fukayama M, et al. Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis. Nat Commun. 2021;12:5947 pubmed publisher
Jorstad N, Wilken M, Todd L, Finkbeiner C, NAKAMURA P, Radulovich N, et al. STAT Signaling Modifies Ascl1 Chromatin Binding and Limits Neural Regeneration from Muller Glia in Adult Mouse Retina. Cell Rep. 2020;30:2195-2208.e5 pubmed publisher
Orlik C, Deibel D, K xfc blbeck J, Balta E, Ganskih S, Habicht J, et al. Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin. Cell Mol Immunol. 2020;17:380-394 pubmed publisher
Zeng G, Lian C, Yang P, Zheng M, Ren H, Wang H. E3-ubiquitin ligase TRIM6 aggravates myocardial ischemia/reperfusion injury via promoting STAT1-dependent cardiomyocyte apoptosis. Aging (Albany NY). 2019;11:3536-3550 pubmed publisher
Odendall C, Dixit E, Stavru F, Bierne H, Franz K, Durbin A, et al. Diverse intracellular pathogens activate type III interferon expression from peroxisomes. Nat Immunol. 2014;15:717-26 pubmed publisher
Hanafi L, Gauchat D, Godin Ethier J, Possamaï D, Duvignaud J, Leclerc D, et al. Fludarabine downregulates indoleamine 2,3-dioxygenase in tumors via a proteasome-mediated degradation mechanism. PLoS ONE. 2014;9:e99211 pubmed publisher
Robinson T, Liu J, Vizeacoumar F, Sun T, MacLean N, Egan S, et al. RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs. PLoS ONE. 2013;8:e78641 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3495

SKU :

3495/10

product name :

Fludarabine

description :

Purine analog; inhibits DNA synthesis

target :

DNA, RNA and Protein Synthesis Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

285.23

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Fludarabine is a purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC50 = 1.54 M in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Inhibits cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in lymphocytes. Also displays anticancer activity against hematological malignancies in vivo .

product keywords :

Purine analog inhibits inhibitors DNA synthesis Proapoptotic increases Bax decreases Bid XIAP survivin expression Apoptosis Inducer STAT1 chemotherapeutics DNA, RNA and Protein Synthesis Apoptosis Inducers STAT 3495,

extended description :

Purine analog; inhibits DNA synthesis

chemical name text :

9- -D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine

formula :

C10H12FN5O4

formula text :

C10H12FN5O4

cas num :

21679-14-1

USD :

189

USD 2025 :

195 USD

product details :

Purine analog; inhibits DNA synthesis

more info or order :

Tocris Bioscience product webpage