product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
ACTH (1-39)
catalog :
3492/1
quantity :
1 mg
price :
493 USD
more info or order :
Tocris Bioscience product webpage
citations: 4
Reference
Piotrowska A, Starnowska Sokół J, Makuch W, Mika J, Witkowska E, Tymecka D, et al. Novel bifunctional hybrid compounds designed to enhance the effects of opioids and antagonize the pronociceptive effects of nonopioid peptides as potent analgesics in a rat model of neuropathic pain. Pain. 2021;162:432-445 pubmed publisher
Nepomuceno D, Kuei C, Dvorak C, Lovenberg T, Liu C, Bonaventure P. Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro. Front Pharmacol. 2018;9:157 pubmed publisher
Nøhr A, Shehata M, Hauser A, Isberg V, Mokrosinski J, Andersen K, et al. The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW. Neurochem Int. 2017;102:105-113 pubmed publisher
Martineau C, Martin Falstrault L, Brissette L, Moreau R. The atherogenic Scarb1 null mouse model shows a high bone mass phenotype. Am J Physiol Endocrinol Metab. 2014;306:E48-57 pubmed publisher
product information
brand :
Tocris
catalog number base :
3492
SKU :
3492/1
product name :
ACTH (1-39)
units size :
1 mg
description :
Potent endogenous MC2 agonist
target :
Melanocortin Receptor Agonists
category :
Peptides
purity :
95%
observed molecular weight :
4541.1
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=peptides
details of functionality :
ACTH (1-39) is a potent endogenous melanocortin receptor 2 (MC2) agonist (EC50 = 57 pM). Component of the hypothalamic-pituitary-adrenal (HPA) axis that stimulates glucocorticoid production and release from the adrenal cortex. Induces insulin resistance, promotes a proinflammatory profile and stimulates UCP-1 in adipocytes in vitro .
top caption :
Potent endogenous MC2 agonist
extended description :
Potent endogenous MC2 agonist
formula :
C207H308N56O58S
formula text :
C207H308N56O58S
cas num :
12279-41-3
USD :
493 USD
product details :
Potent endogenous MC2 agonist
alt names :
Adrenocorticotropic hormone (1-39)
storage :
Store at -20°C
more info or order :
Tocris Bioscience product webpage
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK