UCPH 101 | Tocris Bioscience 3490/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

UCPH 101

catalog :

3490/10

quantity :

10 mg

price :

276 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Brancaccio M, Patton A, Chesham J, Maywood E, Hastings M. Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling. Neuron. 2017;93:1420-1435.e5 pubmed publisher
Tse D, Chung I, Wu S. Pharmacological inhibitions of glutamate transporters EAAT1 and EAAT2 compromise glutamate transport in photoreceptor to ON-bipolar cell synapses. Vision Res. 2014;103:49-62 pubmed publisher
Liang J, Chao D, Sandhu H, Yu Y, Zhang L, Balboni G, et al. ?-Opioid receptors up-regulate excitatory amino acid transporters in mouse astrocytes. Br J Pharmacol. 2014;171:5417-30 pubmed publisher
Dumont A, Goursaud S, Desmet N, Hermans E. Differential regulation of glutamate transporter subtypes by pro-inflammatory cytokine TNF-? in cortical astrocytes from a rat model of amyotrophic lateral sclerosis. PLoS ONE. 2014;9:e97649 pubmed publisher
Okabe Y, Takahashi T, Mitsumasu C, Kosai K, Tanaka E, Matsuishi T. Alterations of gene expression and glutamate clearance in astrocytes derived from an MeCP2-null mouse model of Rett syndrome. PLoS ONE. 2012;7:e35354 pubmed publisher

image

image 1 :

Cat.No. 3490 - UCPH 101 C27H22N2O3 CAS No. 1118460-77-7

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3490

SKU :

3490/10

product name :

UCPH 101

description :

Selective non-substrate EAAT1 inhibitor

target :

Glutamate (EAAT) Transporter Inhibitors

unit size :

10 mg

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

422.48

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

UCPH 101 is a selective non-substrate inhibitor of EAAT1 (IC50 values are 660, 300000 and 300000 nM for EAAT1, EAAT2 and EAAT3 respectively). Also demonstrates no significant inhibition at EAAT4 or EAAT5 in a patch-clamp electrophysiology assay (at final concentration up to 10 M).

product keywords :

Selective non-substrate EAAT1 inhibitors inhibits excitatory amino acid transporters glutamate monoamine neurotransmitter GLAST UCPH101 Glutamate Transporters 3490,

extended description :

Selective non-substrate EAAT1 inhibitor

chemical name text :

2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile

formula :

C27H22N2O3

formula text :

C27H22N2O3

cas num :

1118460-77-7

USD :

267

USD 2025 :

276 USD

product details :

Selective non-substrate EAAT1 inhibitor

more info or order :

Tocris Bioscience product webpage