Astemizole | Tocris Bioscience 3489/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Astemizole

catalog :

3489/50

quantity :

50 mg

price :

109 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Klingerman C, Stipanovic M, Bader M, Lynch C. Second-generation antipsychotics cause a rapid switch to fat oxidation that is required for survival in C57BL/6J mice. Schizophr Bull. 2014;40:327-40 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3489

SKU :

3489/50

product name :

Astemizole

description :

Orally active, potent H1 antagonist; also KV11.1 (hERG) channel blocker

target :

Histamine H1 Receptor Antagonists

unit size :

50 mg

category :

Small Molecules

purity :

99%

storage :

Store at +4°C

observed molecular weight :

458.57

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Astemizole is an orally active, potent histamine H1 antagonist (IC50 = 4 nM) that displays 20-fold, 250-fold and 250-fold selectivity over 5-HT, dopamine and muscarinic acetylcholine receptors respectively. Exhibits antimalarial activity in multidrug resistant strains in vitro (IC50 = 227 - 734 nM). Also potent KV11.1 (hERG) channel blocker (IC50 = 0.9 nM) that displays cardiotoxicity in vivo .

product keywords :

Potent hERG K+ channel blockers histamine H1 antagonists histaminergic Orally active potent Potassium KV Channels Human Ether-A-Go-Go Gene voltage-gated voltage-dependent Receptors Histamine KV11.1 Hismanal Histamine H1 Receptors Voltage-Gated Potassium Channels 3489,

extended description :

Orally active, potent H1 antagonist; also KV11.1 (hERG) channel blocker

chemical name text :

1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine

formula :

C28H31FN4O

formula text :

C28H31FN4O

cas num :

68844-77-9

USD :

107

USD 2025 :

109 USD

product details :

Orally active, potent H1 antagonist; also KV11.1 (hERG) channel blocker

alt names :

Hismanal

more info or order :

Tocris Bioscience product webpage