NH 125 | Tocris Bioscience 3439/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

NH 125

catalog :

3439/10

quantity :

10 mg (also 50 mg)

price :

213 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Xu B, Zhang Y, Du X, Li J, Zi H, Bu J, et al. Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity. Cell Res. 2017;27:882-897 pubmed publisher
Kim W, Conery A, Rajamuthiah R, Fuchs B, Ausubel F, Mylonakis E. Identification of an Antimicrobial Agent Effective against Methicillin-Resistant Staphylococcus aureus Persisters Using a Fluorescence-Based Screening Strategy. PLoS ONE. 2015;10:e0127640 pubmed publisher
Liu X, Zhang L, Wu J, Zhou L, Ren Y, Yang W, et al. Inhibition of elongation factor-2 kinase augments the antitumor activity of Temozolomide against glioma. PLoS ONE. 2013;8:e81345 pubmed publisher
Francis S, Wilke K, Brown D, Carlson E. Mechanistic insight into inhibition of two-component system signaling. Medchemcomm. 2013;4:269-277 pubmed
Cheng Y, Ren X, Zhang Y, Shan Y, Huber Keener K, Zhang L, et al. Integrated regulation of autophagy and apoptosis by EEF2K controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells. Autophagy. 2013;9:208-19 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3439

SKU :

3439/10

product name :

NH 125

description :

CaM kinase III (eEF-2 kinase) inhibitor

target :

CaM Kinase Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

storage :

Desiccate at -20°C

observed molecular weight :

524.56

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

NH 125 is an eukaryotic elongation factor 2 (eEF-2) kinase (CaMK III) inhibitor (IC50 = 60 nM) that displays 125-fold, > 1300-fold and > 1500-fold selectivity over PKC, PKA and CaMK II respectively. Decreases the viability of a variety of cancer cell lines (IC50 values are 0.7 - 4.8 M) and blocks G1/S cell cycle progression. Shown to induce eEF-2 phosphorylation in cancer cells. Also an effective antibacterial agent; inhibits histidine protein kinase in vitro (IC50 = 6.6 M) and in vivo .

product keywords :

CaM kinase III CAMK eEF-2 inhibitors inhibits Histidine protein kinases Calmodulin-Activated calmodulin-dependent Protein NH125 CaM Kinase Other Kinases 3439,

extended description :

CaM kinase III (eEF-2 kinase) inhibitor

chemical name text :

1-Hexadecyl-2-methyl-3-(phenylmethyl)-1H-imidazolium iodide

formula :

C27H45IN2

formula text :

C27H45IN2

cas num :

278603-08-0

USD :

236

USD 2025 :

213 USD

product details :

CaM kinase III (eEF-2 kinase) inhibitor

more info or order :

Tocris Bioscience product webpage