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company name :
Tocris Bioscience
product type :
chemical
product name :
GSK 0660
catalog :
3433/10
quantity :
10 mg (also 50 mg)
price :
269 USD
more info or order :
citations: 20
Reference
Smith D, Martinelli R, Besra G, Illarionov P, Szatmari I, Brazda P, et al. Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties. Psychopharmacology (Berl). 2019;: pubmed publisher
Lee W, Ham S, Lee G, Choi M, Yoo H, Paek K, et al. Activation of peroxisome proliferator-activated receptor delta suppresses BACE1 expression by up-regulating SOCS1 in a JAK2/STAT1-dependent manner. J Neurochem. 2019;151:370-385 pubmed publisher
Halstead A, Kapadia C, Bolzenius J, Chu C, Schriefer A, Wartman L, et al. Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation. elife. 2017;6: pubmed publisher
Wang B, Fu X, Zhu M, Du M. Retinoic acid inhibits white adipogenesis by disrupting GADD45A-mediated Zfp423 DNA demethylation. J Mol Cell Biol. 2017;9:338-349 pubmed publisher
Qian G, Fan W, Ahlemeyer B, Karnati S, Baumgart Vogt E. Peroxisomes in Different Skeletal Cell Types during Intramembranous and Endochondral Ossification and Their Regulation during Osteoblast Differentiation by Distinct Peroxisome Proliferator-Activated Receptors. PLoS ONE. 2015;10:e0143439 pubmed publisher
Niu H, Ku P, Niu C, Cheng J, Lee K. Development of PPAR-agonist GW0742 as antidiabetic drug: study in animals. Drug Des Devel Ther. 2015;9:5625-32 pubmed publisher
Lin C, Tsai J, Chang C, Cheng J, Lin J. Development of telmisartan in the therapy of spinal cord injury: pre-clinical study in rats. Drug Des Devel Ther. 2015;9:4709-17 pubmed publisher
Savage S, McCollum G, Yang R, Penn J. RNA-seq identifies a role for the PPARβ/δ inverse agonist GSK0660 in the regulation of TNFα-induced cytokine signaling in retinal endothelial cells. Mol Vis. 2015;21:568-76 pubmed
Chen T, Shih C, Hsu W, Chou T. Mechanisms of Nifedipine-Downregulated CD40L/sCD40L Signaling in Collagen Stimulated Human Platelets. PLoS ONE. 2015;10:e0127054 pubmed publisher
Fang X, Fang L, Liu A, Wang X, Zhao B, Wang N. Activation of PPAR-δ induces microRNA-100 and decreases the uptake of very low-density lipoprotein in endothelial cells. Br J Pharmacol. 2015;172:3728-36 pubmed publisher
Suarez S, McCollum G, Bretz C, Yang R, Capozzi M, Penn J. Modulation of VEGF-induced retinal vascular permeability by peroxisome proliferator-activated receptor-β/δ. Invest Ophthalmol Vis Sci. 2014;55:8232-40 pubmed publisher
Kim Y, Park K, Kim J, Seo H, Shin K, Lee Y, et al. An endoplasmic reticulum stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating β-defensin production. Mol Cell Biol. 2014;34:4368-78 pubmed publisher
Sharif O, Gawish R, Warszawska J, Martins R, Lakovits K, Hladik A, et al. The triggering receptor expressed on myeloid cells 2 inhibits complement component 1q effector mechanisms and exerts detrimental effects during pneumococcal pneumonia. PLoS Pathog. 2014;10:e1004167 pubmed publisher
Tsai C, Lee K, Chen S, Chen L, Liu K, Cheng J. Decrease of PPARδ in Type-1-Like Diabetic Rat for Higher Mortality after Spinal Cord Injury. PPAR Res. 2014;2014:456386 pubmed publisher
Tsai C, Chan P, Chen L, Chang C, Liu Z, Lin J. Merit of ginseng in the treatment of heart failure in type 1-like diabetic rats. Biomed Res Int. 2014;2014:484161 pubmed publisher
Shih C, Lin I, Ding J, Chen F, Chou T. Antiplatelet activity of nifedipine is mediated by inhibition of NF-κB activation caused by enhancement of PPAR-β/-γ activity. Br J Pharmacol. 2014;171:1490-1500 pubmed publisher
Capozzi M, McCollum G, Savage S, Penn J. Peroxisome proliferator-activated receptor-?/? regulates angiogenic cell behaviors and oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2013;54:4197-207 pubmed publisher
Castillero E, Alamdari N, Aversa Z, Gurav A, Hasselgren P. PPAR?/? regulates glucocorticoid- and sepsis-induced FOXO1 activation and muscle wasting. PLoS ONE. 2013;8:e59726 pubmed publisher
Ramachandran L, Manu K, Shanmugam M, Li F, Siveen K, Vali S, et al. Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor ? activation pathway in gastric cancer. J Biol Chem. 2012;287:38028-40 pubmed publisher
Mottillo E, Bloch A, Leff T, Granneman J. Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply. J Biol Chem. 2012;287:25038-48 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
3433
SKU :
3433/10
product name :
GSK 0660
description :
Selective PPAR antagonist
target :
PPAR delta Receptor Inverse Agonists
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
99%
storage :
Store at +4°C
observed molecular weight :
418.49
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
GSK 0660 is a selective PPAR antagonist (IC50 values are 0.155, 10 and 10 M at PPAR , PPAR and PPAR respectively). Exhibits inverse agonist effects when administered by itself.
product keywords :
Selective PPAR PPARdelta antagonists Peroxisome Proliferator-activating Receptors GSK0660 PPARdelta Receptors 3433,
extended description :
Selective PPAR antagonist
chemical name text :
3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylic acid methyl ester
formula :
C19H18N2O5S2
formula text :
C19H18N2O5S2
cas num :
1014691-61-2
USD :
266
USD 2025 :
269 USD
product details :
Selective PPAR antagonist
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK