CFTRinh 172 | Tocris Bioscience 3430 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CFTRinh 172

catalog :

3430

quantity :

10 mg (also 50 mg)

price :

192 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Delpiano L, Thomas J, Yates A, Rice S, Gray M, Saint Criq V. Esomeprazole Increases Airway Surface Liquid pH in Primary Cystic Fibrosis Epithelial Cells. Front Pharmacol. 2018;9:1462 pubmed publisher
Dasgupta A, Merkel M, Clark M, Jacob A, Dawson J, Manning M, et al. Cell volume changes contribute to epithelial morphogenesis in zebrafish Kupffer's vesicle. elife. 2018;7: pubmed publisher
Bossmann M, Ackermann B, Thome U, Laube M. Signaling Cascade Involved in Rapid Stimulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Dexamethasone. Int J Mol Sci. 2017;18: pubmed publisher
Laube M, Bossmann M, Thome U. Glucocorticoids Distinctively Modulate the CFTR Channel with Possible Implications in Lung Development and Transition into Extrauterine Life. PLoS ONE. 2015;10:e0124833 pubmed publisher
Laube M, Kimpel S, Dietl P, Thome U, Wittekindt O. Benzimidazolones enhance the function of epithelial Na? transport. Br J Pharmacol. 2013;168:1329-40 pubmed publisher

product information

brand :

Tocris

master code :

3430

SKU :

3430/10

product name :

CFTRinh 172

description :

Voltage-independent, selective CFTR chloride channel blocker

target :

CFTR Blockers

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

409.4

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Voltage-independent, selective CFTR chloride channel blocker (Ki = 300 nM) that alters channel gating. Blocks intestinal fluid secretion induced by cholera toxin and Escherichia coli and suppresses cyst growth in animal models of polycystic kidney disease. Orally active. Inhibits mitochondrial respiration and increases reactive oxygen species (ROS) production independently of CFTR in several cell lines.

catalog number base :

3430

product keywords :

Voltage-independent selective CFTR chloride channel blockers Cl- Channels CFTRinh172 CFTR 3430,

extended description :

Voltage-independent, selective CFTR chloride channel blocker

chemical name text :

4-[[4-Oxo-2-thioxo-3-[3-trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]benzoic acid

formula :

C 18 H 10 F 3 NO 3 S 2

formula text :

C18H10F3NO3S2

cas num :

307510-92-5

2020 USD :

188

2021 USD :

192 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage