CFTRinh 172 | Tocris Bioscience 3430/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CFTRinh 172

catalog :

3430/10

quantity :

10 mg (also 50 mg)

price :

250 USD

more info or order :

Tocris Bioscience product webpage

citations: 14

Reference
Laube M, Dornis D, Wenzel F, Thome U. Epidermal growth factor strongly affects epithelial Na+ transport and barrier function in fetal alveolar cells, with minor sex-specific effects. Sci Rep. 2021;11:15951 pubmed publisher
Haq I, Althaus M, Gardner A, Yeoh H, Joshi U, Saint Criq V, et al. Clinical and molecular characterization of the R751L-CFTR mutation. Am J Physiol Lung Cell Mol Physiol. 2021;320:L288-L300 pubmed publisher
Huang J, Lam H, Koziol White C, Limjunyawong N, Kim D, Kim N, et al. The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR. Proc Natl Acad Sci U S A. 2020;117:28485-28495 pubmed publisher
Saint Criq V, Delpiano L, Casement J, Onuora J, Lin J, Gray M. Choice of Differentiation Media Significantly Impacts Cell Lineage and Response to CFTR Modulators in Fully Differentiated Primary Cultures of Cystic Fibrosis Human Airway Epithelial Cells. Cells. 2020;9: pubmed publisher
Menegaz D, Hagan D, Almaca J, Cianciaruso C, Rodriguez Diaz R, Molina J, et al. Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell. Nat Metab. 2019;1:1110-1126 pubmed publisher
Narayanan V, Schappell L, Mayer C, Duke A, Armiger T, Arsenovic P, et al. Osmotic Gradients in Epithelial Acini Increase Mechanical Tension across E-cadherin, Drive Morphogenesis, and Maintain Homeostasis. Curr Biol. 2020;30:624-633.e4 pubmed publisher
Delpiano L, Thomas J, Yates A, Rice S, Gray M, Saint Criq V. Esomeprazole Increases Airway Surface Liquid pH in Primary Cystic Fibrosis Epithelial Cells. Front Pharmacol. 2018;9:1462 pubmed publisher
Dasgupta A, Merkel M, Clark M, Jacob A, Dawson J, Manning M, et al. Cell volume changes contribute to epithelial morphogenesis in zebrafish Kupffer's vesicle. elife. 2018;7: pubmed publisher
Bossmann M, Ackermann B, Thome U, Laube M. Signaling Cascade Involved in Rapid Stimulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Dexamethasone. Int J Mol Sci. 2017;18: pubmed publisher
Uchida H, Machida M, Miura T, Kawasaki T, Okazaki T, Sasaki K, et al. A xenogeneic-free system generating functional human gut organoids from pluripotent stem cells. JCI Insight. 2017;2:e86492 pubmed publisher
Laube M, Bossmann M, Thome U. Glucocorticoids Distinctively Modulate the CFTR Channel with Possible Implications in Lung Development and Transition into Extrauterine Life. PLoS ONE. 2015;10:e0124833 pubmed publisher
Cihil K, Zimnik A, Swiatecka Urban A. c-Cbl reduces stability of rescued ∆F508-CFTR in human airway epithelial cells: Implications for cystic fibrosis treatment. Commun Integr Biol. 2013;6:e23094 pubmed publisher
Laube M, Kimpel S, Dietl P, Thome U, Wittekindt O. Benzimidazolones enhance the function of epithelial Na? transport. Br J Pharmacol. 2013;168:1329-40 pubmed publisher
Cihil K, Ellinger P, Fellows A, Stolz D, Madden D, Swiatecka Urban A. Disabled-2 protein facilitates assembly polypeptide-2-independent recruitment of cystic fibrosis transmembrane conductance regulator to endocytic vesicles in polarized human airway epithelial cells. J Biol Chem. 2012;287:15087-99 pubmed publisher

product information

brand :

Tocris

catalog number base :

3430

SKU :

3430/10

product name :

CFTRinh 172

units size :

10 mg (also 50 mg)

description :

Voltage-independent, selective CFTR chloride channel blocker

target :

CFTR Blockers

category :

Small Molecules

purity :

98%

observed molecular weight :

409.4

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CFTRinh 172 is a voltage-independent, selective CFTR chloride channel blocker (Ki = 300 nM) that alters channel gating. Blocks intestinal fluid secretion induced by cholera toxin and Escherichia coli and suppresses cyst growth in animal models of polycystic kidney disease. Orally active. Inhibits mitochondrial respiration and increases reactive oxygen species (ROS) production independently of CFTR in several cell lines.

top caption :

Voltage-independent, selective CFTR chloride channel blocker

extended description :

Voltage-independent, selective CFTR chloride channel blocker

chemical name text :

4-[[4-Oxo-2-thioxo-3-[3-trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]benzoic acid

formula :

C18H10F3NO3S2

formula text :

C18H10F3NO3S2

cas num :

307510-92-5

USD :

250 USD

product details :

Voltage-independent, selective CFTR chloride channel blocker

storage :

Store at +4Â°C

more info or order :

Tocris Bioscience product webpage