M40 | Tocris Bioscience 3425/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

M40

catalog :

3425/1

quantity :

1 mg

price :

286 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Li S, Huo M, Wu X, Huang Y, Wang L, Zhang X, et al. Involvement of galanin and galanin receptor 1 in nociceptive modulation in the central nucleus of amygdala in normal and neuropathic rats. Sci Rep. 2017;7:15317 pubmed publisher
Goforth P, Leinninger G, Patterson C, Satin L, Myers M. Leptin acts via lateral hypothalamic area neurotensin neurons to inhibit orexin neurons by multiple GABA-independent mechanisms. J Neurosci. 2014;34:11405-15 pubmed publisher
Herring N, Cranley J, Lokale M, Li D, Shanks J, Alston E, et al. The cardiac sympathetic co-transmitter galanin reduces acetylcholine release and vagal bradycardia: implications for neural control of cardiac excitability. J Mol Cell Cardiol. 2012;52:667-76 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3425

SKU :

3425/1

product name :

M40

description :

Potent, non-selective galanin receptor antagonist

target :

Galanin Receptor Antagonists

unit size :

1 mg

category :

Peptides

purity :

95%

storage :

Store at -20°C

observed molecular weight :

1981.33

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=peptides

details of functionality :

M40 is a potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) (Cat. No. 2696) binding in rat brain in vitro (IC50 = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine (Cat. No. 0927) and blocks galanin-induced food intake in vivo . Also exhibits weak partial agonist activity at peripheral GAL2 receptors at doses 100 nM.

product keywords :

Potent non-selective galanin antagonists GAL GalR Receptors Galanin (1-13)-Pro-Pro-(Ala-Leu-)2Ala amide Galanin Receptors 3425,

extended description :

Potent, non-selective galanin receptor antagonist

formula :

C94H145N23O24

formula text :

C94H145N23O24

cas num :

143896-17-7

USD :

283

USD 2025 :

286 USD

product details :

Potent, non-selective galanin receptor antagonist

alt names :

Galanin (1-13)-Pro-Pro-(Ala-Leu-)2Ala amide

more info or order :

Tocris Bioscience product webpage