AC 187 | Tocris Bioscience 3419/500U product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AC 187

catalog :

3419/500U

quantity :

500 ug

price :

419 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Nu xf1 ez Diaz C, Pocevi x10d i x16b t x117 D, Schultz N, Welinder C, Sw xe4 rd K, Wennstr xf6 m M. Contraction of human brain vascular pericytes in response to islet amyloid polypeptide is reversed by pramlintide. Mol Brain. 2023;16:25 pubmed publisher
Liberini C, Borner T, Boyle C, Lutz T. The satiating hormone amylin enhances neurogenesis in the area postrema of adult rats. Mol Metab. 2016;5:834-843 pubmed publisher
Baisley S, Bremer Q, Bakshi V, Baldo B. Antipsychotic-like actions of the satiety peptide, amylin, in ventral striatal regions marked by overlapping calcitonin receptor and RAMP-1 gene expression. J Neurosci. 2014;34:4318-25 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

3419

SKU :

3419/500U

product name :

AC 187

Description :

Potent and selective amylin antagonist

target :

Calcitonin and Related Receptor Antagonists

category :

Peptides

unit size :

500 ug

purity :

95%

observed molecular weight :

2890.25

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=peptides

details of functionality :

AC 187 is an orally active, potent amylin receptor antagonist (IC50 = 0.48 nM) that displays 38-fold and 400-fold selectivity over calcitonin and CGRP receptors respectively. Blocks amyloid -induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro . Increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake in vivo .

extended description :

Potent and selective amylin antagonist

formula :

C 127 H 205 N 37 O 40

formula text :

C127H205N37O40

cas num :

151804-77-2

USD :

419 USD

product details :

Potent and selective amylin antagonist

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage