AC 187 | Tocris Bioscience 3419/500 product information

product summary

request information :

company name :

Tocris Bioscience

product type :

chemical

product name :

AC 187

catalog :

3419/500

quantity :

500µg

price :

285 USD

more info or order :

Tocris Bioscience product webpage

product information

CHEMISTRY :

CC(C)C[C@H](NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O

Cat Number :

3419/500

Product Name :

AC 187

Cas Number :

[151804-77-2]

Unit Size :

500µg

Size :

500

Unit :

µg

USD :

285 USD

Primary Category :

7-TM Receptors

Secondary Category :

Peptide Receptors

Tertiary Category :

Calcitonin and Related Receptors

Primary Action :

Potent and selective amylin receptor antagonist

Biological Description :

Orally active, potent amylin receptor antagonist (IC50 = 0.48 nM) that displays 38-fold and 400-fold selectivity over calcitonin and CGRP receptors respectively. Blocks amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. Increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake in vivo.

Formula :

C127H205N37O40

Molwt :

2890.25

more info or order :

Tocris Bioscience product webpage