CP 99994 dihydrochloride | Tocris Bioscience 3417/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CP 99994 dihydrochloride

catalog :

3417/10

quantity :

10 mg (also 50 mg)

price :

289 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Norton C, Grunz Borgmann E, Hart M, Jones B, Franklin C, Boerman E. Role of perivascular nerve and sensory neurotransmitter dysfunction in inflammatory bowel disease. Am J Physiol Heart Circ Physiol. 2021;320:H1887-H1902 pubmed publisher
Sheahan T, Warwick C, Fanien L, Ross S. The Neurokinin-1 Receptor is Expressed with Gastrin-Releasing Peptide Receptor in Spinal Interneurons and Modulates Itch. J Neurosci. 2020;40:8816-8830 pubmed publisher
Echagarruga C, Gheres K, Norwood J, Drew P. nNOS-expressing interneurons control basal and behaviorally evoked arterial dilation in somatosensory cortex of mice. elife. 2020;9: pubmed publisher
Hahn S, Kim S, Um K, Kim H, Park M. N-benzhydryl quinuclidine compounds are a potent and Src kinase-independent inhibitor of NALCN channels. Br J Pharmacol. 2020;: pubmed publisher
Yin J, Chapman K, Clark L, Shao Z, Borek D, Xu Q, et al. Crystal structure of the human NK1 tachykinin receptor. Proc Natl Acad Sci U S A. 2018;115:13264-13269 pubmed publisher
Wang J, Qi R, Zhou W, Tang Y, Pan L, Cai Y. Differential Gene Expression Profile in the Rat Caudal Vestibular Nucleus is Associated with Individual Differences in Motion Sickness Susceptibility. PLoS ONE. 2015;10:e0124203 pubmed publisher
Horn C, Wang H, Estival L, Meyers K, Magnusson M. Novel dynamic measures of emetic behavior in musk shrews. Auton Neurosci. 2013;179:60-7 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

3417

SKU :

3417/10

product name :

CP 99994 dihydrochloride

Description :

High affinity NK1 antagonist

target :

NK1 Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

369.33

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CP 99994 dihydrochloride is a high affinity NK1 antagonist (Ki = 0.145 nM in vitro ). Also displays high ex vivo binding potency in gerbil striatum (IC50 = 36.8 nM). Attenuates endothelium-dependent contraction induced by substance P.

extended description :

High affinity NK1 antagonist

chemical name text :

(2S,3S)-N-[(2-Methoxyphenyl)methyl]-2-phenyl-3-piperidinamine dihydrochloride

formula :

C 19 H 24 N 2 O.2HCl

formula text :

C19H24N2O.2HCl

cas num :

145148-39-6

USD :

289 USD

product details :

High affinity NK1 antagonist

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage