FAK Inhibitor 14 | Tocris Bioscience 3414 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

FAK Inhibitor 14

catalog :

3414

quantity :

10 mg (also 50 mg)

price :

128 USD

more info or order :

Tocris Bioscience product webpage

citations: 19

Reference
Ni Y, Wang X, Yin X, Li Y, Liu X, Wang H, et al. Plectin protects podocytes from adriamycin-induced apoptosis and F-actin cytoskeletal disruption through the integrin α6β4/FAK/p38 MAPK pathway. J Cell Mol Med. 2018;22:5450-5467 pubmed publisher
Bastounis E, Yeh Y, Theriot J. Matrix stiffness modulates infection of endothelial cells by Listeria monocytogenes via expression of cell surface vimentin. Mol Biol Cell. 2018;29:1571-1589 pubmed publisher
Jia J, Martin T, Ye L, Meng L, Xia N, Jiang W, et al. Fibroblast activation protein-? promotes the growth and migration of lung cancer cells via the PI3K and sonic hedgehog pathways. Int J Mol Med. 2018;41:275-283 pubmed publisher
Visavadiya N, Keasey M, Razskazovskiy V, Banerjee K, Jia C, Lovins C, et al. Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3. Cell Commun Signal. 2016;14:32 pubmed
Rengarajan M, Hayer A, Theriot J. Endothelial Cells Use a Formin-Dependent Phagocytosis-Like Process to Internalize the Bacterium Listeria monocytogenes. PLoS Pathog. 2016;12:e1005603 pubmed publisher
An X, Zhao Z, Luo Y, Zhang R, Tang X, Hao D, et al. Netrin-1 suppresses the MEK/ERK pathway and ITGB4 in pancreatic cancer. Oncotarget. 2016;7:24719-33 pubmed publisher
Webber P, Park C, Qui M, Ramalingam S, Khuri F, Fu H, et al. Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells. Oncoscience. 2015;2:765-776 pubmed
GutiÃ©rrez J, Droppelmann C, Contreras O, Takahashi C, Brandan E. RECK-Mediated Î²1-Integrin Regulation by TGF-Î²1 Is Critical for Wound Contraction in Mice. PLoS ONE. 2015;10:e0135005 pubmed publisher
McLane J, Ligon L. Palladin mediates stiffness-induced fibroblast activation in the tumor microenvironment. Biophys J. 2015;109:249-64 pubmed publisher
Thakur R, Trivedi R, Rastogi N, Singh M, Mishra D. Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer. Sci Rep. 2015;5:10194 pubmed publisher
Shih C, Lacagnina M, Leuer Bisciotti K, Proschel C. Astroglial-derived periostin promotes axonal regeneration after spinal cord injury. J Neurosci. 2014;34:2438-43 pubmed publisher
Wiel C, Augert A, Vincent D, Gitenay D, Vindrieux D, Le Calve B, et al. Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis. Cell Death Dis. 2013;4:e855 pubmed publisher
Maleńczyk K, Jazurek M, Keimpema E, Silvestri C, Janikiewicz J, Mackie K, et al. CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release. J Biol Chem. 2013;288:32685-99 pubmed publisher
Tsai C, Wu H, Lin C, Lin Y, Chao A, Wang T, et al. Estradiol and tamoxifen induce cell migration through GPR30 and activation of focal adhesion kinase (FAK) in endometrial cancers with low or without nuclear estrogen receptor ? (ER?). PLoS ONE. 2013;8:e72999 pubmed publisher
Keasey M, Kang S, Lovins C, Hagg T. Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression. Cell Commun Signal. 2013;11:35 pubmed publisher
Mendoza Naranjo A, El Naggar A, Wai D, Mistry P, Lazic N, Ayala F, et al. ERBB4 confers metastatic capacity in Ewing sarcoma. EMBO Mol Med. 2013;5:1087-102 pubmed publisher
Barbelanne M, Song J, Ahmadzai M, Tsang W. Pathogenic NPHP5 mutations impair protein interaction with Cep290, a prerequisite for ciliogenesis. Hum Mol Genet. 2013;22:2482-94 pubmed publisher
Afrikanova I, Yebra M, Simpkinson M, Xu Y, Hayek A, Montgomery A. Inhibitors of Src and focal adhesion kinase promote endocrine specification: impact on the derivation of ?-cells from human pluripotent stem cells. J Biol Chem. 2011;286:36042-52 pubmed publisher
Tu H, Xu C, Zhang W, Liu Q, Rondard P, Pin J, et al. GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation. J Neurosci. 2010;30:749-59 pubmed publisher

product information

brand :

Tocris

master code :

3414

SKU :

3414/10

product name :

FAK Inhibitor 14

description :

Selective FAK inhibitor

target :

Focal Adhesion Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

observed molecular weight :

284.01

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI. Prevents FAK autophosphorylation at Y397 (IC50 = 1 M), promotes cell detachment and inhibits cell adhesion in vitro . Exhibits antiproliferative activity in a variety of human tumor cell lines in vitro and in breast cancer cells in vivo .

catalog number base :

3414

product keywords :

Selective FAK inhibitors inhibits Focal Adhesion Kinases Inhibitor14 Y15 NSC 677249 Focal Adhesion Kinase 3414,

extended description :

Selective FAK inhibitor

chemical name text :

1,2,4,5-Benzenetetramine tetrahydrochloride

formula :

C 6 H 10 N 4 .4HCl

formula text :

C6H10N4.4HCl

cas num :

4506-66-5

2020 USD :

124

2021 USD :

128 USD

alt names :

Y15, NSC 677249

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage